Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors

被引:0
|
作者
Alluri, Sesha [1 ]
Ganguly, A. K. [1 ]
Caroccia, Danielle [1 ]
Biswas, Dipshikha [1 ]
Wang, Chih-Hung [1 ]
Kang, Eunhee [1 ]
Zhang, Yong [1 ]
McPhail, Andrew T. [2 ]
Carroll, Steven S. [3 ]
Burlein, Christine [3 ]
Munshi, Vandna [3 ]
Orth, Peter [4 ]
Strickland, Corey [4 ]
机构
[1] Stevens Inst Technol, Dept Chem Chem Biol & Biomed Engn, Hoboken, NJ 08854 USA
[2] Duke Univ, Durham, NC 27708 USA
[3] Merck Res Labs, Dept In Vitro Sci, West Point, PA 19486 USA
[4] Merck Res Labs, Dept Struct Chem, Kenilworth, NJ 07033 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
27-ORGN
引用
收藏
页数:1
相关论文
共 50 条
  • [31] NOVEL CONFORMATIONALLY CONSTRAINED HIV-1 PROTEASE INHIBITORS - RATIONAL DESIGN, ENZYME-INHIBITION, AND X-RAY STRUCTURE OF AN ENZYME-INHIBITOR COMPLEX
    KIM, BM
    VACCA, JP
    FITZGERALD, PMD
    DARKE, PL
    HOLLOWAY, MK
    GUARE, JP
    HANIFIN, CM
    ARFORDBICKERSTAFF, DJ
    ZUGAY, JA
    WAI, JM
    ANDERSON, PS
    HUFF, JR
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (18) : 2199 - 2204
  • [32] NOVEL PSEUDOSYMMETRIC INHIBITORS OF HIV-1 PROTEASE
    FAESSLER, A
    ROESEL, J
    GRUETTER, M
    TINTELNOTBLOMLEY, M
    ALTERI, E
    BOLD, G
    LANG, M
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 48 - MEDI
  • [33] X-ray snapshots of HIV-1 protease catalysis and substrate recognition
    Dasa, Amit
    Ferrerb, J. -L.
    Hosura, M. V.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2011, 67 : C425 - C425
  • [34] DESIGN AND SYNTHESIS OF POTENT, ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITORS
    KALDOR, SW
    KALISH, V
    DRESSMAN, BA
    FRITZ, JE
    HAMMOND, M
    CROWELL, TA
    TATLOCK, J
    REICH, S
    DAVIES, J
    APPELT, K
    SHETTY, B
    SU, KS
    CAMPANALE, KM
    BURGESS, JA
    LUBBENHUSEN, PP
    BAXTER, AJ
    MUESING, MA
    HATCH, SD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 17 - MEDI
  • [35] Towards the synthesis of novel boronates as potential HIV-1 protease inhibitors
    Frank, Michael D.
    Faulkner, Andrea L.
    Jennings, Julia J.
    Sigurjonsson, Kristin
    Schreiber, John D.
    Fabry-Asztalos, Levente
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [36] Synthesis of novel borinic acids as potential HIV-1 protease inhibitors
    Jia, Yinshan
    Heer, Tajinder S.
    Nguyen, David V.
    O'Connell, Tracy K.
    Fabry-Asztalos, Levente
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 56 - 56
  • [37] Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
    Murphy, PV
    O'Brien, JL
    Gorey-Feret, LJ
    Smith, AB
    TETRAHEDRON, 2003, 59 (13) : 2259 - 2271
  • [38] X-ray structure of HIV-1 protease in situ product complex
    Bihani, Subhash
    Das, Amit
    Prashar, Vishal
    Ferrer, J. -L.
    Hosur, M. V.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2009, 74 (03) : 594 - 602
  • [39] Toward the synthesis of novel boronates as potential HIV-1 protease inhibitors
    Contreras, Erik M.
    Sigurjonsson, Kristin
    Frank, Michael D.
    Treich, Nicholas
    Fabry-Asztalos, Levente
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [40] Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands
    Ghosh, Arun K.
    Jadhav, Ravindra D.
    Simpson, Hannah
    Kovela, Satish
    Osswald, Heather
    Agniswamy, Johnson
    Wang, Yuan-Fang
    Hattori, Shin-ichiro
    Weber, Irene T.
    Mitsuya, Hiroaki
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 160 : 171 - 182