Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis

被引：8
|
作者：
Nemenoff, Raphael [1 ]
机构：
[1] Univ Colorado Denver, Dept Med, Aurora, CO USA
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 03期
关键词：
lung cancer; PPAR gamma; progression; metastasis; inflammation; macrophages; MACROPHAGES; GROWTH;
D O I：
10.4161/onci.19309
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PPAR gamma activators inhibit cancer cell growth. However the role of these agents in progression/metastasis is not well-defined. Using an orthotopic model of lung cancer, we showed that pioglitazone accelerated progression/metastasis through affects on macrophages. This suggests that potential therapeutic agents may have opposing effects on cancer in different cells.
引用
收藏
页码：402 / 403
页数：2
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