Steroidal saponins from the aerial parts of Cordyline fruticosa L. var. strawberries

被引：12

作者：

Ponou, Beaudelaire K. ^{[1
,2
]}

Teponno, Remy B. ^{[1
]}

Tapondjou, Azefack L. ^{[1
]}

Lacaille-Dubois, Marie-Aleth ^{[3
]}

Quassinti, Luana ^{[4
]}

Bramucci, Massimo ^{[4
]}

Barboni, Luciano ^{[2
]}

机构：

[1] Univ Dschang, Fac Sci, Dept Chem, Res Unit Environm & Appl Chem, Box 183, Dschang, Cameroon

[2] Univ Camerino, Sch Sci & Technol, Chem Div, Via S Agostino 1, I-62032 Camerino, Italy

[3] Univ Bourgogne Franche Comte, Lab Pharmacognosie, UFR Sci Sante, PEPITE EA 4267, Blvd Jeanne dArc,BP 87900, F-21079 Dijon, France

[4] Univ Camerino, Sch Pharm, Physiol Div, Via Gentile III da Varano, I-62032 Camerino, Italy

来源：

FITOTERAPIA | 2019年 / 134卷

关键词：

Cordyline fruticosa; Agavaceae; Steroidal saponins; Fruticoside; Fruticogenin; ANTIOXIDANT TRITERPENE SAPONINS; NMR-SPECTROSCOPY; SAPOGENINS; LEAVES; GLYCOSIDES; STEMS;

D O I：

10.1016/j.fitote.2019.03.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new sulfated steroidal derivative (fruticogenin A: 1-sulfo-australigenin-3-sodium sulphate, 1) and three new steroidal saponins named fruticoside K (3-sulfo-spirostan-25(27)-ene-1 beta-3 beta-diol-1-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-fucopyranoside], 2), fruticoside L (3-sulfo-spirostan-25(27)-ene-1 beta,3 beta,6 alpha-triol-1-O-[alpha-L-rhamnopyranosyl-(1 -> 4)-beta-D-fucopyranosidel, 3) and fruticoside M (spirostan-25(27)-ene-1 beta,3 alpha-diol-1-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-alpha-L-rhamnopyranoside], 4) were isolated from the aerial parts of Cordyline fruticosa L. var. strawberries. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. Compounds 2 and 4 exhibited weak cytotoxicity against melanoma (A375), breast adenocarcinoma (MDA-MB-231), and colon carcinoma (HCT116) human tumor cell lines.

引用

页码：454 / 458

页数：5

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