TARGETING OF LYSYL OXIDASE-LIKE-2 (LOXL2) PROMOTES REVERSAL OF LIVER FIBROSIS VIA INHIBITION OF COLLAGEN CROSS-LINKING AND FIBROTIC MATRIX STABILIZATION

被引：0

作者：

Ikenaga, N. ^{[1
]}

Yoshida, S. ^{[1
]}

Liu, S. B. ^{[1
]}

Chung, J. ^{[1
]}

Sverdlov, D. ^{[1
]}

Marshall, D. ^{[2
]}

Smith, V. ^{[2
]}

Kovalenko, M. ^{[2
]}

Karnik, S. ^{[2
]}

Afdhal, N. ^{[1
]}

Popov, Y. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA

[2] Gilead Sci Inc, Foster City, CA 94404 USA

来源：

JOURNAL OF HEPATOLOGY | 2013年 / 58卷

关键词：

D O I：

10.1016/S0168-8278(13)60598-X

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

596

引用

页码：S243 / S244

页数：2

共 46 条

[21] GENOME-WIDE ASSOCIATION STUDY (GWAS) OF LIVER FIBROSIS PHENOTYPES IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS (PSC) REVEALS COMMON GENETIC VARIATION INFLUENCING SERUM LEVELS OF LYSYL OXIDASE-LIKE-2 (LOXL2)
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JOURNAL OF HEPATOLOGY, 2016, 64 : S180 - S181
[22] Evaluation of Lysyl Oxidase-Like-2 (LOXL2) Expression by Immunohistochemistry (IHC) in Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET): A Retrospective Analysis and Comparison with PTEN
Barriuso, J.
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NEUROENDOCRINOLOGY, 2014, 99 (3-4) : 251 - 252
[23] Collagen cross-linking mediated by lysyl hydroxylase 2: an enzymatic battlefield to combat fibrosis
Piersma, Bram
Bank, Ruud A.
EXTRACELLULAR MATRIX, 2019, 63 (03): : 377 - 387
[24] Selective inhibition of lysyl oxidase like 2 (LOXL2) using a therapeutic monoclonal antibody suppresses the progression of biliary fibrosis in novel PSC-like mouse model
Ikenaga, Naoki
Yoshida, Shuhei
Liu, Susan B.
Chung, Jeanhee
Sverdlov, Deanna
Marshall, Derek
Barry, Vivian
Smith, Victoria
Kovalenko, Maria
Karnik, Satyajit
Afdhal, Nezam H.
Popov, Yury
HEPATOLOGY, 2013, 58 : 581A - 582A
[25] Proteolytic processing of lysyl oxidase-like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV
Lopez-Jimenez, Alberto J.
Basak, Trayambak
Vanacore, Roberto M.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (41) : 16970 - 16982
[26] UTILITY OF SERUM LYSYL OXIDASE-LIKE 2 (LOXL2) MEASUREMENT FOR THE NON-INVASIVE ESTIMATION OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS C INFECTION
Adamkewicz, Joanne I.
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Barry, Vivian
Smith, Victoria
HEPATOLOGY, 2011, 54 : 1224A - 1225A
[27] Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer (vol 77, pg 5846, 2017)
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Martin, Alberto
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Moreno-Bueno, Gema
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Vazquez-Naharro, Alberto
Santamaria, Patricia G.
Morales, Saleta
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Tung, Jason C.
Weaver, Valerie M.
Portillo, Francisco
Cano, Amparo
CANCER RESEARCH, 2023, 83 (06) : 974 - 974
[28] A Monoclonal Antibody Directed at the Lysyl Oxidase-Like 2 (LOXL2) Enzyme Appears Safe and Well Tolerated in Patients with Liver Disease
Talal, Andrew
Feron-Rigodon, Marlene
Madere, Jeannine
He, Lin
Winter, Maria
McHutchison, John G.
Bornstein, Jeffrey
HEPATOLOGY, 2012, 56 : 809A - 809A
[29] LYSYL OXIDASE-MEDIATED CROSS-LINKING IN GRANULATION-TISSUE COLLAGEN IN 2 MODELS OF HYPERGLYCEMIA
REISER, KM
CROUCH, EC
CHANG, K
WILLIAMSON, JR
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1097 (01) : 55 - 61
[30] Novel IrOx/SiO2/W cross-point memory for lysyl-oxidase-like-2 (LOXL2) breast cancer biomarker detection
Jana, S.
Samanta, S.
Roy, S.
Qiu, J. T.
Maikap, S.
2018 INTERNATIONAL SYMPOSIUM ON VLSI TECHNOLOGY, SYSTEMS AND APPLICATION (VLSI-TSA), 2018,

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