Ruthenium(II)-arene complexes with dibenzoylmethane induce apoptotic cell death in multiple myeloma cell lines

被引：27

作者：

Pettinari, Riccardo ^{[1
]}

Marchetti, Fabio ^{[2
]}

Petrini, Agnese ^{[1
]}

Pettinari, Claudio ^{[1
]}

Lupidi, Giulio ^{[1
]}

Fernandez, Bela ^{[3
]}

Dieguez, Antonio Rodriguez ^{[3
]}

Santoni, Giorgio ^{[1
]}

Nabissi, Massimo ^{[1
]}

机构：

[1] Univ Camerino, Sch Pharm, Via S Agostino 1, I-62032 Camerino, MC, Italy

[2] Univ Camerino, Sch Sci & Technol, Via S Agostino 1, I-62032 Camerino, MC, Italy

[3] Univ Granada, Dept Quim Inorgan, Avda Fuentenueva S-N, E-18071 Granada, Spain

来源：

INORGANICA CHIMICA ACTA | 2017年 / 454卷

关键词：

Ru(II)-arene; Dibenzoylmethane; RAPTA; DNA interaction studies; Protein binding studies; Multiple myeloma; RUTHENIUM-ARENE COMPLEXES; ANTITUMOR-ACTIVITY; DNA-BINDING; IN-VITRO; ANTICANCER; COORDINATION; LIGANDS; CHEMISTRY;

D O I：

10.1016/j.ica.2016.04.031

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of ruthenium(II) arene complexes (arene = p-cymene, hexamethylbenzene and benzene) containing dibenzoylmethane ligand (DBMH) of formula I(arene)Ru(DBM)Cl] and their ionic derivatives bearing PTA (1,3,5-triaza-7-phosphaadamantane), of formula Rarene)Ru(DBM)(PTA)]X (X = PF6- or SO3CF3-) have been synthesized and fully characterized. The solid-state structures of five complexes have been determined by single-crystal X-ray diffraction. These ruthenium materials exhibit intense photoluminescence emission at room temperature in the solid state. All complexes effectively bind to calf thymus DNA through intercalative/electrostatic interactions with more affinity for DNA minor groove. Finally, the antitumor activity of both ligand and complexes was evaluated against the U266 and RPMI human multiple myeloma cell lines, and some of them showed a cytotoxic and pro-apoptotic effect toward both cell lines. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：139 / 148

页数：10

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