Carbonic anhydrase IX in malignant pleural mesotheliomas: A potential target for anti-cancer therapy

被引：11

作者：

Kivela, Antti J. ^{[1
]}

Knuuttila, Aija ^{[2
,3
]}

Rasanen, Jari ^{[1
]}

Sihvo, Eero ^{[1
]}

Salmenkivi, Kaisa ^{[4
,5
,6
,7
]}

Saarnio, Juha ^{[8
]}

Pastorekova, Silvia ^{[9
]}

Pastorek, Jaromir ^{[9
]}

Waheed, Abdul ^{[10
]}

Sly, William S. ^{[10
]}

Salo, Jarmo A. ^{[1
]}

Parkkila, Seppo ^{[11
,12
,13
]}

机构：

[1] Univ Helsinki, Cent Hosp, Div Gen Thorac & Esophageal Surg, Dept Cardiothorac Surg, Helsinki 00029, Finland

[2] Univ Helsinki, Div Pulm Med, Dept Med, Helsinki 00029, Finland

[3] Univ Helsinki, Cent Hosp, Helsinki 00029, Finland

[4] Univ Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland

[5] Univ Helsinki, Mol Canc Biol Res Program, FIN-00014 Helsinki, Finland

[6] Helsinki Univ Hosp, HUSLAB, Helsinki 00014, Finland

[7] Univ Helsinki, Dept Virol, Helsinki 00014, Finland

[8] Oulu Univ Hosp, Dept Surg, Oys 90029, Finland

[9] Slovak Acad Sci, Inst Virol, Ctr Mol Med, Bratislava 84505, Slovakia

[10] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[11] Univ Tampere, BioMediTech, Sch Med, FIN-33101 Tampere, Finland

[12] Univ Tampere, Fimlab Ltd, FIN-33101 Tampere, Finland

[13] Tampere Univ Hosp, Tampere, Finland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 06期

基金：

芬兰科学院;

关键词：

Cancer; Carbonic anhydrase; Diagnostics; Expression; Mesothelial cell; Mesothelioma; pH; Pleura; ISOZYME-XII; TUMOR PROGRESSION; POOR-PROGNOSIS; MN/CA IX; EXPRESSION; MARKER; CELLS; FORM;

D O I：

10.1016/j.bmc.2012.09.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Malignant mesothelioma is a neoplasm deriving from mesothelial cells, which line the body cavities. The most common type is malignant pleural mesothelioma (MPM), which is a locally aggressive malignancy with poor prognosis. To improve both the clinical diagnostics and treatment it is necessary to identify novel molecular targets which are characteristic for MPM. Although carbonic anhydrase (CA) enzymes have been linked to pH regulation and spread of cancer cells, they have not been thoroughly studied in MPM specimens. We investigated by immunohistochemistry the expression of CA isozymes II, VII, IX, and XII in a series of 27 histological MPM tumor samples. CA IX was absent in the normal lung alveolar cells, whereas it was abundantly expressed in the normal pleural mesothelium and malignant mesothelioma cells. CA VII also showed weak or moderate reactions in several cases of mesotheliomas. Neither high expression of CA VII nor CA IX did correlate significantly with the survival of the patients. The very high expression of CA IX in MPM suggests that it could represent a novel molecular target for cancer research applications. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1483 / 1488

页数：6

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