One-Pot Synthesis of Amides from Aldehydes and Amines via C-H Bond Activation

被引：103
|
作者：
Cadoni, Roberta [1 ]
Porcheddu, Andrea [1 ]
Giacomelli, Giampaolo [1 ]
De Luca, Lidia [1 ]
机构：
[1] Univ Sassari, Dipartimento Chim & Farm, I-07100 Sassari, Italy
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 19期
关键词：
HYDROCHLORIDE SALTS; STAUDINGER REACTION; ALCOHOLS; CATALYST; WATER; TRANSAMIDATION; AMIDATION; REARRANGEMENT; OXIDATION; PEROXIDE;
D O I：
10.1021/ol302175v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot synthesis of amides from aldheydes with N-chloroamines, prepared in situ from amines, has been developed. Both aliphatic and aromatic aldehydes and many types of mono- and disubstituted amines are tolerant in this transformation. This cross-coupling reaction appears simple and convenient, has a wide substrate scope and makes use of cheap, abundant, and easily available reagents.
引用
收藏
页码：5014 / 5017
页数：4
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