Three-dimensional cellular-level imaging using full-field optical coherence tomography

被引：108
|
作者：
Dubois, A [1 ]
Moneron, G [1 ]
Grieve, K [1 ]
Boccara, AC [1 ]
机构：
[1] CNRS, UPR A0005, Lab Opt Phys, Ecole Super Phys & Chim Ind, F-75231 Paris 5, France
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2004年 / 49卷 / 07期
关键词：
D O I：
10.1088/0031-9155/49/7/010
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
An ultrahigh-resolution full-field optical coherence tomography (OCT) system has been developed for cellular-level imaging of biological media. The system is based on a Linnik interference microscope illuminated with a tungsten halogen lamp, associated with a high-resolution CCD camera. En face tomographic images are produced in real time, with the best spatial resolution ever achieved in OCT (0.7 mum x 0.9 mum, axial x transverse). A shot-noise limited detection sensitivity of 80 dB can be reached with an acquisition time per image of 1 s. Images of animal ophthalmic biopsies and vegetal tissues are shown.
引用
收藏
页码：1227 / 1234
页数：8
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