Serum interleukin-10 levels and adverse events in patients with acute coronary syndrome: a systematic review and meta-analysis

被引:11
|
作者
Liu Jun [1 ]
Jia Yanjun [1 ]
Li Xiaolin [1 ]
Xu Ruixia [1 ]
Zhu Chenggang [1 ]
Guo Yuanlin [1 ]
Wu Naqiong [1 ]
Li Jianjun [1 ]
机构
[1] Chinese Acad Med Sci, Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Div Dyslipidemia,Fu Wai Hosp,State Key Lab Cardio, Beijing 100037, Peoples R China
基金
美国国家科学基金会;
关键词
interleukins; acute coronary syndrome; cardiovascular event; meta-analysis; ANTIINFLAMMATORY CYTOKINE INTERLEUKIN-10; ACUTE MYOCARDIAL-INFARCTION; INDEPENDENT PREDICTOR; HEART-DISEASE; RISK; INFLAMMATION; ELEVATION; ATHEROSCLEROSIS; RATIO; ACTIVATION;
D O I
10.3760/cma.j.issn.0366-6999.20131202
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Several studies investigating the prognostic utility of interleukin-10 (IL-10) in patients with acute coronary syndrome (ACS) have provided conflicting findings. The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events. Methods Literature search was performed in PubMed, EMBASE, and Cochrane Trials Register databases from their inception to September 30, 2012. In addition, reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies. Results A total of 12 eligible studies comprising a total of 5882 patients were identified. The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events. Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable. Conclusions Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS. Large study with longer follow-up is needed to confirm the findings.
引用
收藏
页码:150 / 156
页数:7
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