Retrospective cohort study on risk factors for developing ischemic stroke

被引:1
|
作者
Sadeq, Adel [1 ]
Baraka, Mohamed A. [2 ,3 ]
Hamrouni, Amar [1 ]
Elnour, Asim Ahmed [4 ]
机构
[1] Al Ain Univ, Coll Pharm, Program Clin Pharm, Al Ain, U Arab Emirates
[2] Al Ain Univ, Coll Pharm, Clin Pharm Dept, Al Ain campus, Al Ain, U Arab Emirates
[3] Al Azhar Univ, Coll Pharm, Clin Pharm Dept, Cairo, Egypt
[4] Al Ain Univ, Coll Pharm, AAU Hlth & Biomed Res Ctr, Program Clin Pharm, Abu Dhabi, U Arab Emirates
来源
PHARMACY PRACTICE-GRANADA | 2022年 / 20卷 / 03期
关键词
Ischemic stroke; Model; Modifiable and non-modifiable; Predictors; Risk factors; ADJUSTED LIFE YEARS; GLOBAL BURDEN; ATRIAL-FIBRILLATION; DIABETES-MELLITUS; PREVALENCE; DISEASE; EPIDEMIOLOGY; PREVENTION; MORTALITY; ADULTS;
D O I
10.18549/PharmPract.2022.3.2682
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: There is a paucity of studies describing the risk factors for developing ischemic stroke in our region. Objective: The objective of the current study was to delineate the potential risk factors for the development of ischemic stroke. Methods: We have conducted a retrospective cohort hospitalbased study that has enrolled 231 subjects. The subjects have had presented to the emergency department in a tertiary hospital in the United Arab Emirates. Subjects were diagnosed with ischemic stroke within 24 hours of presentation. Outcome measure: The main outcome measure was the development of ischemic stroke during an indexed hospital visit. Results: The mean age was 47.5 +/- 3.2 with a higher preponderance of males over females (60.9%) and 48.1% were >= 65 years. The final logistic regression model for the development of ischemic stroke contains seven variables. In descending order, the seven predictive risk factors for the development of ischemic stroke were: hypertension (OR 6.1, CI 2.4-9.5; P = 0.029), coronary artery disease (OR 4.2, 3.7-9.1; P = 0.038), low physical activity (OR 4.2, CI 2.1-9.1; P = 0.035), history of previous stroke (OR 4.1, 1.4-3.4; P = 0.033), atrial fibrillation (OR 3.2, CI 2.6-8.2; P = 0.017), family history of stroke (OR 3.1, 1.3-6.9; P = 0.042) and diabetes mellitus (OR 2.7, CI 1.25-6.1; P = 0.035). The specificity of the model was 58.1%; the sensitivity was 86.1%, and the overall accuracy was 75.7%. Conclusion: It is prudent to control modifiable risk factors for the development of strokes such as hypertension, diabetes, atrial fibrillation, coronary artery disease, and low physical activity.
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页数:7
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