Correction of the spontaneous and DEB-induced chromosomal aberrations in Fanconi anemia cells of the FA(C) complementation group by the FACC gene

被引：2
|
作者：
Stavropoulos, DJ
Sood, S
Tomkins, DJ
Buchwald, M
机构：
[1] MCMASTER UNIV,DEPT PEDIAT,HAMILTON,ON L8N 3Z5,CANADA
[2] MCMASTER UNIV,DEPT BIOL,HAMILTON,ON L8N 3Z5,CANADA
[3] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON L8N 3Z5,CANADA
[4] HOSP SICK CHILDREN,RES INST,TORONTO,ON M5G 1X8,CANADA
[5] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON,CANADA
来源：
CYTOGENETICS AND CELL GENETICS | 1996年 / 72卷 / 2-3期
关键词：
D O I：
10.1159/000134187
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fanconi anemia (FA) cells are hypersensitive to the cytotoxic and clastogenic effects of DNA cross-linking agents. Four complementation groups have been identified to date. The gene (FACC) that corrects the hypersensitivity of one of them, FA(C), has been cloned. In the present study, both the increased spontaneous and diepoxybutane (DEB)-induced chromosomal instability in FA(C) lymphoblastoid cells were corrected by transfection of FACC.
引用
收藏
页码：194 / 196
页数：3
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