Correction of the spontaneous and DEB-induced chromosomal aberrations in Fanconi anemia cells of the FA(C) complementation group by the FACC gene

被引：2
|
作者：
Stavropoulos, DJ
Sood, S
Tomkins, DJ
Buchwald, M
机构：
[1] MCMASTER UNIV,DEPT PEDIAT,HAMILTON,ON L8N 3Z5,CANADA
[2] MCMASTER UNIV,DEPT BIOL,HAMILTON,ON L8N 3Z5,CANADA
[3] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON L8N 3Z5,CANADA
[4] HOSP SICK CHILDREN,RES INST,TORONTO,ON M5G 1X8,CANADA
[5] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON,CANADA
来源：
CYTOGENETICS AND CELL GENETICS | 1996年 / 72卷 / 2-3期
关键词：
D O I：
10.1159/000134187
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Fanconi anemia (FA) cells are hypersensitive to the cytotoxic and clastogenic effects of DNA cross-linking agents. Four complementation groups have been identified to date. The gene (FACC) that corrects the hypersensitivity of one of them, FA(C), has been cloned. In the present study, both the increased spontaneous and diepoxybutane (DEB)-induced chromosomal instability in FA(C) lymphoblastoid cells were corrected by transfection of FACC.
引用
收藏
页码：194 / 196
页数：3
相关论文
共 50 条
  • [1] ECORI RFLP IN THE FANCONI-ANEMIA COMPLEMENTATION GROUP-C GENE (FACC)
    GIBSON, RA
    SAVOIA, A
    BUCHWALD, M
    MATHEW, CG
    HUMAN MOLECULAR GENETICS, 1993, 2 (09) : 1509 - 1509
  • [2] REPRESSION OF THE FANCONI ANEMIA COMPLEMENTATION GROUP-C GENE (FACC) INHIBITS NORMAL HEMATOPOIESIS INVITRO
    SEGAL, GM
    MAGENIS, E
    BROWN, M
    SMITH, TD
    KEEBLE, W
    BAGBY, GC
    CLINICAL RESEARCH, 1993, 41 (02): : A276 - A276
  • [3] Retroviral gene transfer for the assignment of Fanconi anemia (FA) patients to a FA complementation group
    Kai-Ling Fu
    Peter C. Thuß
    Tadahiro Fujino
    Martin Digweed
    Johnson M. Liu
    Christopher E. Walsh
    Human Genetics, 1998, 102 : 166 - 169
  • [4] Retroviral gene transfer for the assignment of Fanconi anemia (FA) patients to a FA complementation group
    Fu, KL
    Thuss, PC
    Fujino, T
    Digweed, M
    Liu, JM
    Walsh, CE
    HUMAN GENETICS, 1998, 102 (02) : 166 - 169
  • [5] COMPLEMENTATION OF FANCONI-ANEMIA GROUP-C (FACC) CELLS WITH FACC CDNA CORRECTS SPECIFIC DRUG-INDUCED CYTOTOXICITY AND CELL-CYCLE ARREST
    KUPFER, GM
    DANDREA, AD
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 325 - 325
  • [6] FANCONI-ANEMIA COMPLEMENTATION GROUP-C (FACC) CARRIER SCREENING AND GENETIC-MAPPING
    AUERBACH, AD
    SHIN, HT
    KAPORIS, AG
    QIAN, L
    ZHANG, O
    VERLANDER, PC
    BLOOD, 1994, 84 (10) : A504 - A504
  • [7] FANCONI-ANEMIA COMPLEMENTATION GROUP-C (FACC) CARRIER TESTING AND GENETIC-MAPPING
    AUERBACH, AD
    VERLANDER, PC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1995, : 294 - 294
  • [8] CHARACTERIZATION OF THE 5' REGION OF THE FANCONI-ANEMIA GROUP-C (FACC) GENE
    SAVOIA, A
    CENTRA, M
    LANZANO, L
    DECILLIS, GP
    ZELANTE, L
    BUCHWALD, M
    HUMAN MOLECULAR GENETICS, 1995, 4 (08) : 1321 - 1326
  • [9] IMMUNOLOGICAL SCREENING OF THE FANCONI-ANEMIA COMPLEMENTATION GROUP-C (FACC) POLYPEPTIDE IDENTIFIES CANDIDATE PATIENTS FOR GENE-THERAPY
    YAMASHITA, T
    GROMPE, M
    WU, N
    CORLESS, C
    DANDREA, AD
    BLOOD, 1994, 84 (10) : A743 - A743
  • [10] The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality
    Pang, QS
    Christianson, TA
    Keeble, W
    Diaz, J
    Faulkner, GR
    Reifsteck, C
    Olson, S
    Bagby, GC
    BLOOD, 2001, 98 (05) : 1392 - 1401
12345