New synthesis of ethambutol and related α,β-acetylenic amino alcohols

被引：3
|
作者：
Mavrov, M. V. [1 ]
Simirskaya, N. I. [1 ]
机构：
[1] Russian Acad Sci, Zelinskii Inst Organ Chem, Moscow, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2013年 / 46卷 / 12期
关键词：
ethambutol; alpha-bromoallenic alcohol; vicinal amino alcohols; N-derivatives of hydroxyamino-alkynes; allenyl substitution; enantiomeric separation; ANTITUBERCULOUS AGENTS; (S; S)-ETHAMBUTOL;
D O I：
10.1007/s11094-013-0880-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ethambutol was obtained in 35% overall yield in three steps by enantiomeric separation of rac-2-benzylamino-3-butyl-1-ol, alkylation of the S-enantiomer with 1,2-dibromoethane, and catalytic N-debenzylation.
引用
收藏
页码：730 / 735
页数：6
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