Structure-activity relationships of pyrazine-based CK2 inhibitors: Synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines

被引：26

作者：

Suzuki, Yarnato ^{[1
]}

Cluzeau, Jerome ^{[1
]}

Hara, Takafumi ^{[1
]}

Hirasawa, Akira ^{[1
]}

Tsujimoto, Gozoh ^{[1
]}

Oishi, Shinya ^{[1
]}

Ohno, Hiroaki ^{[1
]}

Fujii, Nobutaka ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

ARCHIV DER PHARMAZIE | 2008年 / 341卷 / 09期

关键词：

CK2; glomerulonephritis; kinase inhibitor; pyrazine derivatives; SAR study;

D O I：

10.1002/ardp.200700269

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structually related to the known CK2 inhibitors, 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives were synthesized and their inhibitory activities toward CK2 alpha and CK2 alpha' were evaluated. Structure-activity relationship study has revealed that several pyrazine derivatives bearing a (pyrrol-3-yl)acetic acid and a monosubstituted aniline possess potent inhibitory activities.

引用

页码：554 / 561

页数：8

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