Chronic hepatitis E in a heart transplant patient: sofosbuvir and ribavirin regimen not fully effective

被引：23

作者：

Todesco, Eve ^{[1
,2
]}

Mazzola, Alessandra ^{[3
]}

Akhavan, Sepideh ^{[2
,4
]}

Abravanel, Florence ^{[5
,6
]}

Poynard, Thierry ^{[7
,8
,9
]}

Roque-Afonso, Anne-Marie ^{[10
]}

Peytavin, Gilles ^{[11
,12
]}

Marcelin, Anne-Genevieve ^{[1
,2
]}

Calmus, Yvon ^{[3
]}

Lecuyer, Lucien ^{[13
]}

Guillemain, Romain ^{[14
]}

Conti, Filomena ^{[3
]}

机构：

[1] UPMC Univ Paris 06, Sorbonne Univ, INSERM, IPLESP,UMRS 1136, Paris, France

[2] Hop La Pitie Salpetriere, AP HP, Dept Virol, Paris, France

[3] UPMC Paris VI, Hop Pitie Salpetriere, AP HP, Unite Med Transplantat Hepat,Hepatogastroenterol, Blvd Hop, Paris, France

[4] UPMC Univ Paris 06, Sorbonne Univ, CIMI Paris UMRS CR7, PVI Team,Inserm,U1135, Paris, France

[5] CHU Toulouse, Hop Purpan, Lab Virol, Natl Reference Ctr Hepatitis E, Toulouse, France

[6] INSERM, Ctr Physiopathol Toulouse Purpan, U1043, Toulouse, France

[7] Grp Hosp Pitie Salpetriere, AP HP, Paris, France

[8] UPMC Univ Paris 06, Sorbonne Univ, UMR S 938, Paris, France

[9] INSERM, Inst Cardiometab & Nutr ICAN, Paris, France

[10] Univ Paris Sud, Hop Paul Brousse, AP HP, INSERM,Virol,U1193, Villejuif, France

[11] Bichat Claude Bernard Hosp, AP HP, Pharmacotoxicol Dept, Paris, France

[12] Univ Paris Diderot, Sorbonne Paris Cite, IAME, INSERM,UMR 1137, Paris, France

[13] Univ Paris 05, Hop Europeen Georges Pompidou, AP HP, Serv Chirurg Cardiovasc, Paris, France

[14] Hop Europeen Georges Pompidou, AP HP, Pole Cardiovasc Nephrol Hypertens Diabet, Unite Fonct Transplantat Thorac, Paris, France

来源：

ANTIVIRAL THERAPY | 2018年 / 23卷 / 05期

关键词：

E VIRAL-INFECTION; REPLICATION;

D O I：

10.3851/IMP3227

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Hepatitis E virus (HEV) can induce chronic infections in the case of immunosuppression, which are sometimes not cured with ribavirin. Furthermore, sofosbuvir is a highly potent inhibitor of HCV polymerase and was shown to inhibit HEV genotype-3 replication in vitro. We report here the outcome of sofosbuvir/ribavirin therapy on a chronic HEV infection in a heart transplant recipient non-responder to ribavirin. After 24 weeks, the regimen failed to cure the persistent HEV infection, highlighting the need of therapeutic options for HEV-infected immunosuppressed patients.

引用

页码：463 / 465

页数：3

共 50 条

[41] Therapeutic windowfor ribavirin therapy in transplant recipients with chronic hepatitis E virus infection
Mulder, Midas
De Man, Robert
Kamar, Nassim
Durmaz, Gulcan
de Bruijne, Joep
Vanwolleghem, Thomas
Van der Eijk, Annemiek
Van Gelder, Teun
Hesselink, Dennis
De Winter, Brenda
JOURNAL OF HEPATOLOGY, 2020, 73 : S855 - S856
[42] Determining the therapeutic range for ribavirin in transplant recipients with chronic hepatitis E virus infection
Mulder, Midas B.
de Man, Robert A.
Kamar, Nassim
Durmaz, Gulcan
de Bruijne, Joep
Vanwolleghem, Thomas
Izopet, Jacques
Gandia, Peggy
van Der Eijk, Annemiek A.
van Gelder, Teun
Hesselink, Dennis A.
de Winter, Brenda C. M.
JOURNAL OF VIRAL HEPATITIS, 2021, 28 (02) : 431 - 435
[43] Successful Treatment of Chronic Hepatitis E After an Orthotopic Liver Transplant With Ribavirin Monotherapy
Klein, Fritz
Neuhaus, Ruth
Hofmann, Joerg
Rudolph, Birgit
Neuhaus, Peter
Bahra, Marcus
EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 2015, 13 (03) : 283 - 286
[44] Therapeutic window for ribavirin therapy in transplant recipients with chronic hepatitis E virus infection
Mulder, M. B.
de Man, R. A.
Kamar, N.
Durmaz, G.
de Bruijne, J.
Vanwolleghem, T.
Izopet, J.
Gandia, P.
van der Eijk, A. A.
van Gelder, T.
Hesselink, D. A.
de Winter, B. C. M.
TRANSPLANTATION, 2021, 105 (08) : 91 - 92
[45] RIBAVIRIN FOR TREATMENT OF CHRONIC HEPATITIS E IN TRANSPLANT RECIPIENTS - EXPERIENCE FROM OUR CENTRE
Boyd, Alexander
Bufton, Sally
Mutimer, David Mutimer
Elsharkawy, Ahmed
GUT, 2018, 67 : A107 - A108
[46] Sofosbuvir and ribavirin in acute hepatitis C-infected patient with decompensated cirrhosis
Liu, Hui
Zhang, Tong
Yan, Yan
MEDICINE, 2016, 95 (49) : e5555
[47] A Case for Ribavirin to Treat Chronic Hepatitis E
Thomas, David L.
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (12): : 1162 - 1163
[48] Ribavirin for Chronic Hepatitis E Virus Infection
Brochot, Etienne
Choukroun, Gabriel
Duverlie, Gilles
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (25): : 2446 - 2447
[49] Sofosbuvir and Ribavirin is safe and effective therapy in chronic hepatitis C patients with end-stage renal disease on haemodialysis
Nayak, Sumanlata
Sharma, Manoj
Mathur, Rajendra P.
Varma, Prem Prakash
Gupta, Ekta
Choudhary, Ashok
Jamwal, Kapil D.
Maiwall, Rakhi
Kumar, Guresh
Bhardwaj, Ankit
Sarin, Shiv K.
HEPATOLOGY, 2016, 64 : 425A - 425A
[50] Localized scleroderma occurring after treatment of chronic hepatitis C with sofosbuvir and ribavirin
Waki, Yuma
Kamiya, Koji
Maekawa, Takeo
Komine, Mayumi
Murata, Satoru
Ohtsuki, Mamitaro
JOURNAL OF DERMATOLOGY, 2019, 46 (01): : E34 - E35

← 1 2 3 4 5 →