Synthesis and antiviral activity of benzimidazolyl- and triazolyl-1,3,5-triazines

被引：20

作者：

Maarouf, Azza R. ^{[1
]}

Farahat, Abdelbasset A. ^{[2
]}

Selim, Khalid B. ^{[2
]}

Eisa, Hassan M. ^{[2
]}

机构：

[1] Mansoura Univ, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt

[2] Mansoura Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Mansoura 35516, Egypt

来源：

MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 06期

关键词：

1,3,5-Triazines; Benzimidazoles; 1,2,4-Triazoles; Antiviral; Anti-HSV-1; ANTITUMOR-ACTIVITY; DERIVATIVES; INHIBITORS; ANTIBACTERIAL; TRIAZINES; ANALOGS; HIV; DNA;

D O I：

10.1007/s00044-011-9574-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 mu g/ml, SI = 358; for compound 5r: EC50 = 5.0 mu g/ml, SI = 300) in comparison to acyclovir.

引用

页码：703 / 710

页数：8

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