Synthesis and antiviral activity of benzimidazolyl- and triazolyl-1,3,5-triazines

被引：20
|
作者：
Maarouf, Azza R. [1 ]
Farahat, Abdelbasset A. [2 ]
Selim, Khalid B. [2 ]
Eisa, Hassan M. [2 ]
机构：
[1] Mansoura Univ, Dept Med Chem, Fac Pharm, Mansoura 35516, Egypt
[2] Mansoura Univ, Dept Organ Pharmaceut Chem, Fac Pharm, Mansoura 35516, Egypt
来源：
MEDICINAL CHEMISTRY RESEARCH | 2012年 / 21卷 / 06期
关键词：
1,3,5-Triazines; Benzimidazoles; 1,2,4-Triazoles; Antiviral; Anti-HSV-1; ANTITUMOR-ACTIVITY; DERIVATIVES; INHIBITORS; ANTIBACTERIAL; TRIAZINES; ANALOGS; HIV; DNA;
D O I：
10.1007/s00044-011-9574-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 mu g/ml, SI = 358; for compound 5r: EC50 = 5.0 mu g/ml, SI = 300) in comparison to acyclovir.
引用
收藏
页码：703 / 710
页数：8
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