Sensitivity of a point of care tick-test for the development of Lyme borreliosis

被引：4

作者：

Sprong, Hein ^{[1
]}

van Leeuwen, Arieke Docters ^{[1
]}

Fonville, Manoj ^{[1
]}

Harms, Margriet ^{[1
]}

van Vliet, Arnold J. ^{[2
]}

van Pelt, Wilfrid ^{[1
]}

Ferreira, Jose A. ^{[1
]}

van den Wijngaard, Cees C. ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control Netherlands, NL-3720 BA Bilthoven, Netherlands

[2] Wageningen Univ, Environm Syst Anal Grp, NL-6700 AP Wageningen, Netherlands

来源：

PARASITES & VECTORS | 2013年 / 6卷

关键词：

Lyme borreliosis; Self-test; Ixodes ricinus; Validation; Post-exposure prophylaxis; BORNE DISEASES; IXODES-RICINUS; NETHERLANDS; EUROPE; BITE;

D O I：

10.1186/1756-3305-6-338

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Background: A commercially available self-test for the detection of Borrelia burgdorferi sensu lato in ticks was evaluated for its ability to predict erythema migrans formation. Findings: The self-test was performed on 127 Ixodes ricinus from 122 humans that reported tick bites at enrolment and occurrence of symptoms during follow-up. The self-test gave negative results on all the 122 individuals, 14 of whom reported erythema migrans (EM) at follow-up of which 10 were confirmed by their GP. The estimated sensitivity of the self-test for prediction of EM formation is 0% (95% Cl: 0%-28%). Conclusions: This self-test is not suitable for reducing the number needed to treat in a post-exposure prophylaxis setting as it already missed all the obvious early Lyme borreliosis cases.

引用

页数：3

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