miRNA regulation of cytokine genes

被引：130
|
作者：
Asirvatham, Ananthi J. [1 ]
Magner, William J. [1 ]
Tomasi, Thomas B. [1 ,2 ,3 ]
机构：
[1] Roswell Pk Canc Inst, Mol Med Lab, Dept Immunol, Buffalo, NY 14263 USA
[2] SUNY Buffalo, Sch Med & Biomed Sci, Dept Med, Buffalo, NY 14214 USA
[3] SUNY Buffalo, Sch Med & Biomed Sci, Dept Microbiol & Immunol, Buffalo, NY 14214 USA
来源：
CYTOKINE | 2009年 / 45卷 / 02期
关键词：
miRNA; ARE; Cytokine; Chemokine; Evolution; MESSENGER-RNA STABILITY; TUMOR-NECROSIS-FACTOR; TRANSFORMING-GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; AU-RICH ELEMENTS; NF-KAPPA-B; VIRUS-INDUCED LYMPHOMAS; TGF-BETA; POSTTRANSCRIPTIONAL REGULATION; HUMAN CANCER;
D O I：
10.1016/j.cyto.2008.11.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：58 / 69
页数：12
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