Outcomes Among HIV-Positive Patients Hospitalized With COVID-19

被引:135
|
作者
Karmen-Tuohy, Savannah [1 ]
Carlucci, Philip M. [1 ]
Zervou, Fainareti N. [1 ]
Zacharioudakis, Ioannis M. [1 ]
Rebick, Gabriel [1 ]
Klein, Elizabeth [1 ]
Reich, Jenna [1 ]
Jones, Simon [2 ,3 ]
Rahimian, Joseph [1 ]
机构
[1] NYU, Dept Med, Grossman Sch Med, 550 1St Ave, New York, NY 10016 USA
[2] NYU Grossman Sch Med, Dept Populat Hlth, Div Healthcare Delivery Sci, New York, NY USA
[3] NYU Langone Hlth, Ctr Healthcare Innovat & Delivery Sci, New York, NY USA
关键词
HIV; COVID-19; SARS-CoV-2; coronavirus; BACTERIAL PNEUMONIA; THERAPY;
D O I
10.1097/QAI.0000000000002423
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: SARS-CoV-2 infection continues to cause significant morbidity and mortality worldwide. Preliminary data on SARS-CoV-2 infection suggest that some immunocompromised hosts experience worse outcomes. We performed a retrospective matched cohort study to characterize outcomes in HIV-positive patients with SARS-CoV-2 infection. Methods: Leveraging data collected from electronic medical records for all patients hospitalized at NYU Langone Health with COVID-19 between March 2, 2020, and April 23, 2020, we matched 21 HIV-positive patients with 42 non-HIV patients using a greedy nearest-neighbor algorithm. Admission characteristics, laboratory test results, and hospital outcomes were recorded and compared between the 2 groups. Results: Although there was a trend toward increased rates of intensive care unit admission, mechanical ventilation, and mortality in HIV-positive patients, these differences were not statistically significant. Rates for these outcomes in our cohort are similar to those previously published for all patients hospitalized with COVID-19. HIV-positive patients had significantly higher admission and peak C-reactive protein values. Other inflammatory markers did not differ significantly between groups, although HIV-positive patients tended to have higher peak values during their clinical course. Three HIV-positive patients had superimposed bacterial pneumonia with positive sputum cultures, and all 3 patients died during hospitalization. There was no difference in frequency of thrombotic events or myocardial infarction between these groups. Conclusions: This study provides evidence that HIV coinfection does not significantly impact presentation, hospital course, or outcomes of patients infected with SARS-CoV-2, when compared with matched non-HIV patients. A larger study is required to determine whether the trends we observed apply to all HIV-positive patients.
引用
收藏
页码:6 / 10
页数:5
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