Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma

被引：70
|
作者：
Akintunde, Marjannie Eloi [1 ,2 ]
Rose, Melissa [2 ,3 ,4 ]
Krakowiak, Paula [3 ,4 ]
Heuer, Luke [1 ,3 ]
Ashwood, Paul [2 ,3 ,5 ]
Hansen, Robin [2 ,3 ,6 ]
Hertz-Picciotto, Irva [2 ,3 ,4 ]
de Water, Judy Van [1 ,2 ,3 ]
机构：
[1] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Sch Med, Davis, CA 95616 USA
[2] Univ Calif Davis, NIEHS Ctr Childrens Environm Hlth, Davis, CA 95616 USA
[3] Univ Calif Davis, MIND Inst, Davis, CA 95616 USA
[4] Univ Calif Davis, Sch Publ Hlth Sci, Davis, CA 95616 USA
[5] Sch Med, Dept Microbiol & Immunol, Washington, DC USA
[6] Univ Calif Davis, Sch Med, Dept Pediat, Davis, CA 95616 USA
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 286卷
关键词：
Autism; IL-17; Asthma; Food allergies; T-CELLS; IMMUNE; INTERLEUKIN-17; LYMPHOCYTES; ENVIRONMENT; EXPRESSION; RESPONSES; RISK;
D O I：
10.1016/j.jneuroim.2015.07.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Inflammation and asthma have both been reported in some children with autism spectrum disorder (ASD). To further assess this connection, peripheral immune cells isolated from young children with ASD and typically developing (TD) controls and the production of cytokines IL-17, -13, and -4 assessed following ex vivo mitogen stimulation. Notably, IL-17 production was significantly higher following stimulation in ASD children compared to controls. Moreover, IL-17 was increased in ASD children with co-morbid asthma compared to controls with the same condition. In conclusion, children with ASD exhibited a differential response to T cell stimulation with elevated IL-17 production compared to controls. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：33 / 41
页数：9
相关论文
共 50 条
  • [21] Differences in natural course of asthma in children with or without co-morbid allergic rhinitis
    Radic, S.
    Zivkovic, Z.
    Cerovic, S.
    Krivokapic, T.
    Calovic, O.
    Vera, A.
    ALLERGY, 2011, 66 : 196 - 197
  • [22] Health burden of co-morbid asthma and allergic rhinitis in West Indian children
    Pereira, L. M. Pinto
    Jackman, J.
    Figaro, N.
    Babootee, N.
    Cudjoe, G.
    Farrell, S.
    Francis-Regis, C.
    Henry, K. Garcia
    Pandor, A.
    Walters, T.
    Bekele, I.
    ALLERGOLOGIA ET IMMUNOPATHOLOGIA, 2010, 38 (03) : 129 - 134
  • [23] Detection of IL-17 and IL-23 in plasma samples of children with autism
    Department of Medical Microbiology and Immunology, M.I.N.D. Institute, University of California, Davis, CA, United States
    不详
    不详
    不详
    不详
    不详
    Am. J. Biochem. Biotechnol., 2008, 2 (114-120):
  • [24] Long term antibiotic therapy may be an effective treatment for children co-morbid with Lyme disease and Autism Spectrum Disorder
    Kuhn, Mason
    Grave, Shannon
    Bransfield, Robert
    Harris, Steven
    MEDICAL HYPOTHESES, 2012, 78 (05) : 606 - 615
  • [25] Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder
    Chonchaiya, Weerasak
    Au, Jacky
    Schneider, Andrea
    Hessl, David
    Harris, Susan W.
    Laird, Meredith
    Mu, Yi
    Tassone, Flora
    Nguyen, Danh V.
    Hagerman, Randi J.
    HUMAN GENETICS, 2012, 131 (04) : 581 - 589
  • [26] Increased prevalence of seizures in boys who were probands with the FMR1 premutation and co-morbid autism spectrum disorder
    Weerasak Chonchaiya
    Jacky Au
    Andrea Schneider
    David Hessl
    Susan W. Harris
    Meredith Laird
    Yi Mu
    Flora Tassone
    Danh V. Nguyen
    Randi J. Hagerman
    Human Genetics, 2012, 131 : 581 - 589
  • [27] Increased serum IL-17 is an independent risk factor for severe asthma
    Agache, Ioana
    Ciobanu, Cristina
    Agache, Costel
    Anghel, Mariana
    RESPIRATORY MEDICINE, 2010, 104 (08) : 1131 - 1137
  • [28] Prevalence of sleep problems among children and adolescents with co-morbid psychiatric disorders
    Werthwein, R
    Michaelidis, T
    Lewin, DS
    SLEEP, 2005, 28 : A101 - A102
  • [29] Behavior Disorders and Social Skills in Adolescents with Intellectual Disability: Does Co-Morbid Autism Matter?
    Baker, Bruce L.
    Blacher, Jan
    JOURNAL OF MENTAL HEALTH RESEARCH IN INTELLECTUAL DISABILITIES, 2021, 14 (02) : 174 - 188
  • [30] ANTICHOLINERGIC TREATMENT FOR ASTHMA IN CHILDREN WITH CO-MORBID DEPRESSION: AN APPROACH TO TARGETING A VULNERABLE POPULATION
    Miller, Bruce D.
    Lehman, Heather K.
    Wood, Beatrice L.
    PSYCHOSOMATIC MEDICINE, 2022, 84 (05): : A120 - A121
12345