SYNTHESIS OF PYRAZOLES THROUGH COPPER-CATALYZED THREE-COMPONENT COUPLING OF ALDEHYDES, ALKYNES, AND p-TOLUENESULFONYLHYDRAZIDE

被引：3
|
作者：
Wu, Feng [1 ]
Hao, Lu [2 ]
Zhan, Zhuang-ping [1 ,2 ]
机构：
[1] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Fujian, Peoples R China
[2] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China
来源：
HETEROCYCLES | 2013年 / 87卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Pyrazole; Copper-Catalyzed Coupling Reaction; ONE-POT SYNTHESIS; TERMINAL ALKYNES; SECONDARY-AMINES; EFFICIENT; CYCLIZATION; QUINOLINES; DIHYDROPYRAZOLES; HYDRAZONES; HYDRAZINES; REAGENT;
D O I：
10.3987/COM-12-12646
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient one-pot synthesis of 3,5-disubstitued 1H-pyrazoles through copper-catalyzed three-component coupling of aldehydes, alkynes, and p-toluenesulfonylhydrazide has been developed. This method provides a flexible and rapid route to 3,5-disubstituted 1H-pyrazoles.
引用
收藏
页码：657 / 663
页数：7
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