Engineering Nanoparticles for Targeted Delivery of Nucleic Acid Therapeutics in Tumor

被引：94
|
作者：
Xiao, Yao [1 ,2 ,3 ]
Shi, Kun [1 ,2 ,3 ]
Qu, Ying [1 ,2 ,3 ]
Chu, Bingyang [1 ,2 ,3 ]
Qian, Zhiyong [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
[2] Sichuan Univ, West China Med Sch, West China Hosp, Ctr Canc, Chengdu, Sichuan, Peoples R China
[3] Collaborat Innovat Ctr, Chengdu, Sichuan, Peoples R China
来源：
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | 2019年 / 12卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
CALCIUM-PHOSPHATE NANOPARTICLES; LOW-MOLECULAR-WEIGHT; BIOREDUCIBLE POLY(AMIDO AMINE)S; SOLID LIPID NANOPARTICLES; BREAST-CANCER CELLS; GENE DELIVERY; GOLD NANOPARTICLES; SIRNA DELIVERY; DRUG-DELIVERY; IN-VITRO;
D O I：
10.1016/j.omtm.2018.09.002
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the past 10 years, with the increase of investment in clinical nano-gene therapy, there are many trials that have been discontinued due to poor efficacy and serious side effects. Therefore, it is particularly important to design a suitable gene delivery system. In this paper, we introduce the application of lipo-somes, polymers, and inorganics in gene delivery; also, different modifications with some stimuli-responsive systems can effectively improve the efficiency of gene delivery and reduce cytotoxicity and other side effects. Besides, the co-delivery of chemotherapy drugs with a drug tolerance-related gene or oncogene provides a better theoretical basis for clinical cancer gene therapy.
引用
收藏
页码：1 / 18
页数：18
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