Targeted Delivery of Nucleic Acid-Based Therapeutics to the Pulmonary Circulation

被引：18
|
作者：
Kuruba, Ramalinga [1 ]
Wilson, Annette [1 ]
Gao, Xiang [1 ]
Li, Song [1 ]
机构：
[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Ctr Pharmacogenet, Pittsburgh, PA 15261 USA
来源：
AAPS JOURNAL | 2009年 / 11卷 / 01期
基金：
美国国家卫生研究院;
关键词：
delivery; endothelial cells; genes; lung; oligonucleotides; pulmonary circulation; siRNA; targeting; CELLS IN-VITRO; MOUSE LUNG; ENDOTHELIAL-CELLS; GENE DELIVERY; ANTISENSE OLIGONUCLEOTIDES; CATIONIC LIPOSOME; PLASMID DNA; EXPRESSION; VIVO; UROKINASE;
D O I：
10.1208/s12248-008-9073-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed.
引用
收藏
页码：23 / 30
页数：8
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