Purpose: The purpose of this pilot study was to examine the effect of a Chinese traditional exercise program, Qigong Yi Jinjing (QYJJ), on patients with chronic obstructive pulmonary disease (COPD). Methods: One hundred and thirty eligible COPD patients were randomly divided into three groups: the QYJJ group (n=42), the self-management exercise group (n=43), and the control group (n=45). Data were collected and analyzed at baseline and again at one, three, and six months. A pulmonary rehabilitation index, consisting of pulmonary function, six-minute walk test, Regulatory Emotion Self-Efficacy questionnaire, and exercise of the COPD Assessment Test widely used to evaluate health-related quality of life (HRQL) in participants with COPD, was measured. Results: Compared with the other groups, participants in QYJJ group had significantly better lung function (forced expiratory volume in one second: F=8.96, p=0.000; forced expiratory volume in one second/forced vital capacity: F=11.55, p=0.000; the percentage of forced expiratory volume in one second in prediction: F=24.27, p=0.000); walked a longer distance (F=152.52, p=0.000), and had more satisfactory HRQL (F=14.08, p=0.000). QYJJ training also contributed to improving the ability of emotion regulation (F=36.56, p=0.000). There were significant positive changes in expressing positive affect (F=56.25, p=0.000) and managing despondency/distress (F=21.58, p=0.000), apart from the ability to regulate anger/irritation (F=1.20, p=0.305). The longer QYJJ is practiced, the more effective the influence is on the pulmonary rehabilitation-related index measures. Conclusions: These results indicate that QYJJ exercise produced positive effects on pulmonary function, physical activity, emotion regulation self-efficiency (modulating the expression of despondency or distress and experiencing and expressing positive affect), and HRQL in patients with COPD.