The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain

被引：41
|
作者：
Gurpinar, Tugba [1 ]
Ekerbicer, Nuran [2 ]
Uysal, Nazan [3 ]
Barut, Turgay [4 ]
Tarakci, Figen [5 ]
Tuglu, M. Ibrahim [6 ]
机构：
[1] Celal Bayar Univ, Fac Med, Dept Pharmacol, TR-45030 Manisa, Turkey
[2] Celal Bayar Univ, Fac Med, Dept Physiol, TR-45030 Manisa, Turkey
[3] Dokuz Eylul Univ, Fac Med, Dept Physiol, TR-35340 Izmir, Turkey
[4] Celal Bayar Univ, Fac Med, Dept Histol & Embriol, TR-45030 Manisa, Turkey
[5] Celal Bayar Univ, Dept Vocat Sch Hlth Serv, TR-45030 Manisa, Turkey
[6] Celal Bayar Univ, Fac Med, Dept Histol, TR-45030 Manisa, Turkey
来源：
SCIENTIFIC WORLD JOURNAL | 2012年
关键词：
NITRIC-OXIDE SYNTHASE; PHYSIOLOGICAL CONCENTRATIONS; CEREBRAL-ISCHEMIA; RATS; STREPTOZOTOCIN; ACTIVATION; PANCREAS; INHIBIT; INJURY; DEATH;
D O I：
10.1100/2012/498489
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Oxidative stress plays an important role in the development of complications in diabetes mellitus. Antioxidant therapy has been thought to decrease oxidative stress. The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods. Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats. MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week. Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT). Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats. It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.
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页数：5
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