Ianthelliformisamines A-C, Antibacterial Bromotyrosine-Derived Metabolites from the Marine Sponge Suberea ianthelliformis

被引：38

作者：

Xu, Min ^{[1
]}

Davis, Rohan A. ^{[1
]}

Feng, Yunjiang ^{[1
]}

Sykes, Melissa L. ^{[1
]}

Shelper, Todd ^{[1
]}

Avery, Vicky M. ^{[1
]}

Camp, David ^{[1
]}

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 05期

基金：

澳大利亚研究理事会;

关键词：

MULTIDRUG-RESISTANCE; MECHANISMS; DERIVATIVES; ALKALOIDS;

D O I：

10.1021/np300147d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A high-throughput screening campaign using a prefractionated natural product library and an in vitro Pseudomonas aeruginosa (PAO200 strain) assay identified two antibacterial fractions derived from the marine sponge Suberea ianthelliformis. Mass-directed isolation of the CH2Cl2/CH3OH extract from S. ianthelliformis resulted in the purification of three new bromotyrosine-derived metabolites, ianthelliformisamines A-C (1-3), together with the known natural products aplysamine 1 (4) and araplysillin I (5). The structures of 1-3 were determined following analysis of 1D and 2D NMR and MS spectroscopic data. This is the first report of chemistry from the marine sponge S. ianthelliformis. Ianthelliformisamine A (1) showed inhibitory activity against the Gram-negative bacterium P. aeruginosa with an IC50 value of 6.8 mu M (MIC = 35 mu M).

引用

页码：1001 / 1005

页数：5

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