A Case of Papuloerythroderma Successfully Treated with Dupilumab

被引：3
|
作者：
Mizuno, Ayaka [1 ]
Habe, Koji [1 ]
Matsushima, Yoshiaki [1 ]
Kondo, Makoto [1 ]
Yamanaka, Keiichi [1 ]
机构：
[1] Mie Univ, Grad Sch Med, Dept Dermatol, Tsu, Japan
来源：
CASE REPORTS IN DERMATOLOGY | 2022年 / 14卷 / 02期
关键词：
Papuloerythroderma; Dupilumab; Th2; IL-4; IL-13;
D O I：
10.1159/000524716
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching. Topical or oral corticosteroids are treatment measures, but immunosuppressive drugs are sometimes required. Herein, we report a case of papuloerythroderma treated with dupilumab, a completely humanized immunoglobulin monoclonal antibody against interleukin-4 receptor subunit alpha (IL-4R alpha) of IL-4 and IL-13 receptors, with rapid and marked improvement. Dupilumab is one of the treatment options to treat refractory papuloerythroderma.
引用
收藏
页码：117 / 122
页数：6
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