Syntheses of Two Co(II) and Ni(II) Complexes with 2-(1H-Imidazolyl-1-methyl)-1H-benzimidazole and 1,4-Benzenedicarboxylate Ligands and Their Effect on Cardiac Fibroblasts Proliferation

Two new isostructural complexes based on 2-(1H-imidazolyl-1-methyl)-1H-benzimidazole (imb) and di-anionic 1,4-benzenedicarboxylate (bdic), namely, {[Co(bdic)(imb)(2)(H2O)(2)]center dot 2H(2)O}(n) (1) and {[Ni(bdic)(imb)(2)(H2O)(2)]center dot 2H(2)O}(n) (2), have been synthesized and characterized by single-crystal X-ray diffraction. Both complexes possess a chain structure with the di-anionic bdic groups bridging the metal ions. The imb ligands coordinate the metal ions in a monodentate mode at two sides of the main chain. These chains are further packed into 3D networks through five kinds of hydrogen bonds. The in vitro effect of 1 and 2 on cultured cardiac fibroblasts (CF) proliferation in the presence or absence of excessive angiotensin II (AngII) have been investigated by a flow cytometric assay. The results have indicated that both complexes have no obvious effect on the cell cycle distribution of CF, but they can suppress the CF proliferation induced by AngII.