SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

被引：11

作者：

Ortiz, Sergio ^{[1
]}

Nelson, Ronald ^{[1
]}

Kesternich, Victor ^{[1
]}

Perez-Fehrmann, Marcia ^{[1
]}

Christen, Philippe ^{[2
]}

Marcourt, Laurence ^{[2
]}

机构：

[1] Univ Catolica Norte, Dept Quim, Av Angamos 0610, Antofagasta, Chile

[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2016年 / 61卷 / 03期

关键词：

Antifungal Activity; Diarylhydrazones; Schiff bases; SCHIFF-BASES; BIOLOGICAL-ACTIVITIES; IN-VITRO; DERIVATIVES; COMPLEXES;

D O I：

10.4067/S0717-97072016000300015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.

引用

页码：3081 / 3084

页数：4

共 50 条

[11] REACTION OF 2,4-DINITROPHENYLHYDRAZINE WITH ARALKYL ALCOHOLS
PATAI, S
DAYAGI, S
JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (12): : 2014 - 2016
[12] THE REACTION OF ADRENOCORTICAL HORMONES WITH 2,4-DINITROPHENYLHYDRAZINE
REICH, H
SAMUELS, BK
JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (01): : 65 - 67
[13] ANHYDRIDE ACYLATION REACTIONS OF 2,4-DINITROPHENYLHYDRAZINE
HEARN, MJ
DEFURIO, L
HURST, W
KOSS, C
LICTHMAN, M
LUCAS, L
MABROUK, P
TENG, S
WAUD, C
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1982, 14 (06) : 406 - 409
[14] KINETICS OF THE ADDITION OF KETONES WITH 2,4-DINITROPHENYLHYDRAZINE
RAO, TS
GUNJAL, PS
CURRENT SCIENCE, 1984, 53 (09): : 479 - 480
[15] THE OXIDATION OF GLYCOLS WITH 2,4-DINITROPHENYLHYDRAZINE HYDROCHLORIDE
WELTI, D
WHITTAKER, D
CHEMISTRY & INDUSTRY, 1962, (22) : 986 - 986
[16] THE REACTION OF SIMPLE KETOLS WITH 2,4-DINITROPHENYLHYDRAZINE
REICH, H
SAMUELS, BK
JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (01): : 68 - 71
[17] IDENTIFICATION OF CRYSTALLINE PROGESTERONE WITH 2,4-DINITROPHENYLHYDRAZINE
KLEIN, D
WEINER, N
GORDON, SM
ANALYTICAL CHEMISTRY, 1948, 20 (02) : 174 - 176
[18] Synthesis and Bioassay of Novel Phenylhydrazine and 2,4-Dinitrophenylhydrazine Substituted Carbazoles
Hamid, Almas
Sadiq, Zubi
Yaqub, Ghazala
Khan, Nikhat
Iqbal, Saira
Iqbal, Kashaf
Ijaz, Zainab
Bajwa, Anum
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (10) : 5412 - 5414
[19] THE REACTION OF STEROID KETONES WITH 2,4-DINITROPHENYLHYDRAZINE
REICH, H
CRANE, KF
SANFILIPPO, SJ
JOURNAL OF ORGANIC CHEMISTRY, 1953, 18 (07): : 822 - 832
[20] Oxidative chemiluminescence assay of 2,4-dinitrophenylhydrazine
Townshend, A
Wheatley, RA
ANALYST, 1998, 123 (05) : 1041 - 1046

← 1 2 3 4 5 →