SYNTHESIS AND ANTIFUNGAL ACTIVITY OF DIARYL HYDRAZONES FROM 2,4-DINITROPHENYLHYDRAZINE

被引：11

作者：

Ortiz, Sergio ^{[1
]}

Nelson, Ronald ^{[1
]}

Kesternich, Victor ^{[1
]}

Perez-Fehrmann, Marcia ^{[1
]}

Christen, Philippe ^{[2
]}

Marcourt, Laurence ^{[2
]}

机构：

[1] Univ Catolica Norte, Dept Quim, Av Angamos 0610, Antofagasta, Chile

[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2016年 / 61卷 / 03期

关键词：

Antifungal Activity; Diarylhydrazones; Schiff bases; SCHIFF-BASES; BIOLOGICAL-ACTIVITIES; IN-VITRO; DERIVATIVES; COMPLEXES;

D O I：

10.4067/S0717-97072016000300015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of diarylhydrazones derived from 2,4-dinitrophenylhydrazine were synthesized via condensation with aromatic aldehydes whose structures have been determined by mass spectrometry, infrared spectroscopy, and nuclear magnetic resonance spectra. Yields were 50-99%. All compounds were screened in vitro for their antifungal activity. Preliminary results indicated that compounds 3g and 3h exhibited promising antifungal potency. Understanding of the structure of these compounds establishes a preliminary structure-activity relationship to form the basis of further investigation.

引用

页码：3081 / 3084

页数：4

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