A Novel Mechanism for Acquiring GPCR Effector Selectivity

被引:0
|
作者
Guy-David, Liora [1 ]
Reuveny, Eitan [1 ]
机构
[1] Weizmann Inst Sci, IL-76100 Rehovot, Israel
关键词
D O I
10.1016/j.bpj.2012.11.2981
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:538A / 538A
页数:1
相关论文
共 50 条
  • [31] A novel mechanism for the modulation of the Ras-effector interaction by small molecules
    Spoerner, M
    Graf, T
    König, B
    Kalbitzer, HR
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 334 (02) : 709 - 713
  • [32] A novel mechanism of response selectivity of neurons in cat visual cortex
    Volgushev, M
    Pernberg, J
    Eysel, UT
    JOURNAL OF PHYSIOLOGY-LONDON, 2002, 540 (01): : 307 - 320
  • [33] SELECTIVITY AND MECHANISM OF ACTION OF NOVEL DNA-CLEAVING SULFONES
    NICOLAOU, KC
    WENDEBORN, S
    MALIGRES, P
    ISSHIKI, K
    ZEIN, N
    ELLESTAD, G
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (04): : 418 - 420
  • [34] A Structural Understanding of Class B GPCR Selectivity and Activation Revealed
    Krumm, Brian
    Roth, Bryan L.
    STRUCTURE, 2020, 28 (03) : 277 - 279
  • [35] Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule
    Egyed, Attila
    Kelemen, Adam A.
    Vass, Marton
    Visegrady, Andras
    Thee, Stephanie A.
    Wang, Zhiyong
    de Graaf, Chris
    Brea, Jose
    Isabel Loza, Maria
    Leurs, Rob
    Keseru, Gyorgy M.
    BIOORGANIC CHEMISTRY, 2021, 111
  • [36] Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies
    Schlimgen, Roman R.
    Peterson, Francis C.
    Heukers, Raimond
    Smit, Martine J.
    McCorvy, John D.
    Volkman, Brian F.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [37] The evolution and mechanism of GPCR proton sensing
    Rowe, Jacob B.
    Kapolka, Nicholas J.
    Taghon, Geoffrey J.
    Morgan, William M.
    Isom, Daniel G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
  • [38] GPCR-G protein selectivity revealed by structural pharmacology
    Bernhard, Sarah M.
    Han, Jianming
    Che, Tao
    FEBS JOURNAL, 2024, 291 (13) : 2784 - 2791
  • [39] Coevolution underlies GPCR-G protein selectivity and functionality
    Seo, Min Jae
    Heo, Joongyu
    Kim, Kyunghui
    Chung, Ka Young
    Yu, Wookyung
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [40] Illuminating the complexity of GPCR pathway selectivity - advances in biosensor development
    Wright, Shane C.
    Bouvier, Michel
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2021, 69 : 142 - 149