Cytotoxic abietane diterpenoids from Salvia leriifolia Benth

被引：3

作者：

Sarhadi, Elham ^{[1
]}

Ebrahimi, Samad Nejad ^{[2
]}

Hadjiakhoondi, Abbas ^{[1
,3
]}

Abbas-Mohammadi, Mahdi ^{[4
]}

Manayi, Azadeh ^{[1
]}

Parisi, Valentina ^{[5
]}

Pessolano, Emanuela ^{[5
]}

Petrella, Antonello ^{[5
]}

De Tommasi, Nunziatina ^{[5
]}

机构：

[1] Univ Tehran Med Sci, Med Plants Res Centr, Fac Pharm, Tehran, Iran

[2] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Pharmacognosy, Fac Pharm, Tehran, Iran

[4] Univ Kashan, Dept Organ Chem, Fac Chem, Kashan, Iran

[5] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy

来源：

PHYTOCHEMISTRY | 2022年 / 202卷

关键词：

Salvia leriifolia; Lamiaceae; Diterpenoids; NMR; AGS cell; Phytochemical; LABDANE DITERPENOIDS; EXTRACTS; CONSTITUENTS; ANTIOXIDANT; TAXOQUINONE; SAHENDICA; GROWTH; ROOTS; ASSAY; BARK;

D O I：

10.1016/j.phytochem.2022.113310

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Phytochemical profiling of the root extract of Salvia leriifolia, an endemic plant of Iran, was investigated and 16 abietane diterpenes were isolated, and three were original compounds. 1D and 2D NMR and HRMS performed structural elucidation. The absolute configuration of the previously unreported compounds was determined by circular dichroism (ECD). The cytotoxicity of the isolated compounds was investigated against AGS, MIA PaCa-2, HeLa, and MCF-7 cell lines by the MTT assay. The known diterpene pisiferal possesses high cytotoxicity against all investigated cell lines at a concentration between 9.3 +/- 0.6 and 14.38 +/- 1.4 mu M.

引用

页数：7

共 50 条

[31] ABIETANE TYPE DITERPENOIDS FROM SALVIA-MILTIORRHIZA
IKESHIRO, Y
MASE, I
TOMITA, Y
PHYTOCHEMISTRY, 1989, 28 (11) : 3139 - 3141
[32] Abietane Diterpenoids from the Hairy Roots of Salvia corrugata
Kentsop, Romeo Arago Dougue
Iobbi, Valeria
Donadio, Giuliana
Ruffoni, Barbara
De Tommasi, Nunziatina
Bisio, Angela
MOLECULES, 2021, 26 (17):
[33] Abietane diterpenoids as butyrylcholinesterase inhibitors from Salvia species
Topcu, G.
Akdemir, A.
Ozturk, M.
Boga, M.
Kola, U.
PLANTA MEDICA, 2012, 78 (11) : 1229 - 1229
[34] ABIETANE DITERPENOIDS FROM THE ROOT OF SALVIA-LAVANDULAEFOLIA
MICHAVILA, A
FERNANDEZGADEA, F
RODRIGUEZ, B
PHYTOCHEMISTRY, 1985, 25 (01) : 266 - 268
[35] Cytotoxic abietane diterpenoids from Caryopteris incana
Gao, JJ
Han, GQ
PHYTOCHEMISTRY, 1997, 44 (04) : 759 - 761
[36] Cytotoxic diterpenoids from Salvia yunnanensis
Wu, Chun-Yan
Liao, Yang
Yang, Zi-Gang
Yang, Xing-Wei
Shen, Xiao-Ling
Li, Rong-Tao
Xu, Gang
PHYTOCHEMISTRY, 2014, 106 : 171 - 177
[37] Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling
Fahimeh Moradi-Afrapoli
Mohammad Shokrzadeh
Fatemeh Barzegar
Gilar Gorji-Bahri
Reza Zadali
Samad Nejad Ebrahimi
Revista Brasileira de Farmacognosia, 2018, 28 : 27 - 33
[38] Cytotoxic activity of abietane diterpenoids from roots of Salvia sahendica by HPLC-based activity profiling
Moradi-Afrapoli, Fahimeh
Shokrzadeh, Mohammad
Barzegar, Fatemeh
Gorji-Bahri, Gilar
Zadali, Reza
Ebrahimi, Samad Nejad
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, 2018, 28 (01): : 27 - 33
[39] Novel rearranged abietane diterpenoids from the roots of Salvia sahendica
Jassbi, Amir Reza
Mehrdad, Morteza
Eghtesadi, Farrokh
Ebrahimi, Samad Nejad
Baldwin, Ian T.
CHEMISTRY & BIODIVERSITY, 2006, 3 (08) : 916 - 922
[40] Modified abietane diterpenoids and a methoxylupane derivative from Salvia palaestina
Hussein, AA
delaTorre, MC
Rodriguez, B
Hammouda, FM
Hussiney, HA
PHYTOCHEMISTRY, 1997, 45 (08) : 1663 - 1668

← 1 2 3 4 5 →