SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 1,3,4-OXADIAZOLE INCORPORATED BENZOXAZOLES

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作者
Basavaraja, B. M. [1 ]
Vagdevi, H. M. [1 ]
Srikrishna, L. P. [1 ]
Shubha, B. S. [1 ]
Vaidya, V. P. [2 ]
机构
[1] Kuvempu Univ, Dept Ind Chem, Shankaraghatta 577451, India
[2] Kuvempu Univ, Dept Gen Chem, Shankaraghatta 577451, India
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中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The compounds 5-[(1,3-benzoxazol-2-yl-thio) methyl]-1,3,4-oxadiazole-2-thiols 3a-b have been synthesized from 2-[(5-methyl-1,3-benzoxazol-2-yl) thio] aceto hydrazides 2a-b by refluxing with carbon disulphide in presence of alcoholic potassium hydroxide. The title compounds 5-[(1,3-benzoxazol-2-yl-thio) methyl]-3-{[(4-substitutedphenyl) amino] methyl)-1,3,4-oxadiazolidine-2-thiones 4a-p were prepared from 5-[(1,3-benzoxazol-2yl-thio) methyl]-4,5-dihydro-1,3,4-oxadiazole-2-thiones 3a-b by stirring with formaldehyde and appropriate aromatic amines in ethanol. All the synthesized compounds were characterized by spectral data and evaluated for antimirobial activity by cup plate method. Many compounds were found to exhibit significant antibacterial and antifungal activities.
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页码:5 / 8
页数:4
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