Synthesis and antimicrobial activity of some 1,3,4-oxadiazole derivatives

被引:181
|
作者
Sahin, G
Palaska, E [1 ]
Ekizoglu, M
Özalp, M
机构
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-06100 Ankara, Turkey
来源
FARMACO | 2002年 / 57卷 / 07期
关键词
1,3,4-oxadiazole-2(3H)-thione; 1,3,4-oxadiazole-2(3H)-one; 2-amino-1,3,4-oxadiazole; synthesis; antimicrobial activity;
D O I
10.1016/S0014-827X(02)01245-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Six new 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-thione, 2-amino-5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole, 5-(1-/ 2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one derivatives have been synthesized from 1-and/or 2-naphthol. The structures,of the compounds were confirmed by IR and H-1 NMR spectral data and microanalysis. The antimicrobial properties of the compounds were investigated against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, Candida albicans, C. krusei and C. parapsilosis using microbroth dilution method. 2-Amino-5-(2-naphthytoxymethyl)-1,3,4-oxadiazole and 5-(2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one show significantly (32 mug/ml), compounds 5-(1-/2-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-thione, 2-amino-5-(1-naphthyloxymethyl)-1,3,4-oxadiazole and 5-(1-naphthyloxymethyl)-1,3,4-oxadiazole-2(3H)-one moderately (64 mug/ml) active against C. krusei. All the compounds were active against S. a ureus,. coli, P. aeruginosa, C. albicans, and C. parapsilosis at 64-256 mug/ml concentration. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:539 / 542
页数:4
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