Palladium-Catalyzed Propargylic [n+2] Cycloaddition: An Efficient Strategy for Construction of Benzo-Fused Medium-Sized Heterocycles

被引：4
|
作者：
Liu, Zhen-Ting [1 ,2 ]
Hu, Xiang-Ping [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 04期
基金：
中国国家自然科学基金;
关键词：
A regioselective palladium-catalyzed formal [n+2] cycloaddition of propargylic esters as C-2-synthons with various linker-tethered bisphenols for the construction of medium-sized heterocycles bearing an exocyclic double bond has been developed; The reaction features mild conditions and broad substrate scopes; as well as readily available substrates and catalysts; Under optimal conditions; various medium-sized heterocycles from eight to eleven-membered rings can be afforded in good to excellent yields and regioselectivities with high Z-selectivity for the exocyclic double bond; palladium; medium-sized ring; propargylic ester; bisphenol; cycloaddition; 1,3-DIPOLAR 3+6 CYCLOADDITION; RING-EXPANSION; AZOMETHINE YLIDES; ENANTIOSELECTIVE SYNTHESIS; CONVERGENT STRATEGIES; ALLYLIC COMPOUNDS; ACCESS; ANNULATION; DERIVATIVES; CYCLIZATION;
D O I：
10.1002/adsc.201801359
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
No Abstract. (Figure presented.). © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
引用
收藏
页码：836 / 841
页数：6
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