CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids

被引：12

作者：

Link, Achim ^{[1
]}

Zhou, Yujing ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 14期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

ENANTIOSELECTIVE CONJUGATE REDUCTION; ADDITION-REACTIONS; AMIDES; CARBOXAMIDES; HYDROGENATION; PERSPECTIVE; REAGENTS; COMPLEX;

D O I：

10.1021/acs.orglett.0c02064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct enantioselective copper hydride (CuH)-catalyzed synthesis of beta-chiral amides from alpha,beta-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the beta-position including several heteroarenes. A subsequent iridium-catalyzed reduction to gamma-chiral amines can be performed in the same flask without purification of the intermediate amides.

引用

页码：5666 / 5670

页数：5

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