CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids

被引：12
|
作者：
Link, Achim [1 ]
Zhou, Yujing [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 14期
基金：
美国国家卫生研究院; 瑞士国家科学基金会;
关键词：
ENANTIOSELECTIVE CONJUGATE REDUCTION; ADDITION-REACTIONS; AMIDES; CARBOXAMIDES; HYDROGENATION; PERSPECTIVE; REAGENTS; COMPLEX;
D O I：
10.1021/acs.orglett.0c02064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The direct enantioselective copper hydride (CuH)-catalyzed synthesis of beta-chiral amides from alpha,beta-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the beta-position including several heteroarenes. A subsequent iridium-catalyzed reduction to gamma-chiral amines can be performed in the same flask without purification of the intermediate amides.
引用
收藏
页码：5666 / 5670
页数：5
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