Allogeneic Stem Cell Transplantation for Myelodysplastic Syndrome Patients with a 5q Deletion

被引：12

作者：

Garderet, Laurent ^{[1
]}

Ziagkos, Dimitris ^{[2
]}

Van Biezen, Anja ^{[3
]}

Lacobelli, Simona ^{[4
]}

Finke, Juergen ^{[5
]}

Maertens, Johan ^{[6
]}

Volin, Liisa ^{[7
]}

Ljungman, Per ^{[8
]}

Chevallier, Patrice ^{[9
]}

Passweg, Jakob ^{[10
]}

Schaap, Nicolaas ^{[11
]}

Beelen, Dietrich ^{[12
]}

Nagler, Arnon ^{[13
]}

Blaise, Didier ^{[14
]}

Poire, Xavier ^{[15
]}

Yakoub-Agha, Ibrahim ^{[16
]}

Lenhoff, Stig ^{[17
]}

Craddock, Charles ^{[18
]}

Schots, Rik ^{[19
]}

Rambaldi, Alessandro ^{[20
]}

Sanz, Jaime ^{[21
,22
]}

Jindra, Pavel ^{[23
]}

Mufti, Ghulam J. ^{[24
]}

Robin, Marie ^{[25
]}

Kroeger, Nicolaus ^{[26
]}

机构：

[1] Hosp St Antoine, Dept Haematol, Paris, France

[2] Leiden Univ, Med Ctr, EBMT Data Off, Leiden, Netherlands

[3] EBMT Data Off Leiden, Leiden, Netherlands

[4] Tor Vergata Univ Rome, Dept Med Stat, Rome, Italy

[5] Univ Freiburg, Dept Haematol, Freiburg, Germany

[6] Univ Hosp Gasthuisberg, Dept Haematol, Leuven, Belgium

[7] HUCH Comprehens Canc Ctr, Dept Haematol, Helsinki, Finland

[8] Karolinska Univ Hosp, Dept Haematol, Stockholm, Sweden

[9] CHU Nantes, Dept Haematol, Nantes, France

[10] Univ Hosp, Dept Haematol, Basel, Switzerland

[11] Radboud Univ Nijmegen, Med Ctr, Dept Haematol, Nijmegen, Netherlands

[12] Univ Hosp, Dept Haematol, Essen, Germany

[13] Chaim Sheba Med Ctr, Dept Haematol, Tel Hashomer, Israel

[14] Ctr Rech Cancerol Marseille, Dept Haematol, Marseille, France

[15] Clin Univ St Luc, Dept Haematol, Brussels, Belgium

[16] Hosp Huriez, Dept Haematol, Lille, France

[17] Skanes Univ Hosp, Dept Haematol, Lund, Sweden

[18] Ctr Clin Haematol, Dept Haematol, Birmingham, W Midlands, England

[19] Univ Ziekenhuis Brussel, Dept Haematol, Brussels, Belgium

[20] Azienda Osped Papa Giovanni XXIII, Dept Haematol, Bergamo, Italy

[21] Univ Valencia, Univ Hosp La Fe, Dept Haematol, Valencia, Spain

[22] Inst Carlos III, Ctr Invest Biomed Red Canc, Dept Haematol, Madrid, Spain

[23] Charles Univ Hosp, Dept Haematol, Plzen, Czech Republic

[24] GKT Sch Med, Dept Haematol, London, England

[25] Hosp St Louis, Dept Haematol, Paris, France

[26] Univ Hosp Eppendorf, Dept Haematol, Hamburg, Germany

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2018年 / 24卷 / 03期

关键词：

MDS; del (5q); Allogeneic stem cell transplantation; PROGNOSTIC SCORING SYSTEM; MARROW-TRANSPLANTATION; EUROPEAN-SOCIETY; TP53; MUTATIONS; WORKING PARTY; DEL(5Q); LENALIDOMIDE; IMPACT; CHROMOSOME; BLOOD;

D O I：

10.1016/j.bbmt.2017.11.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The deletion (5q) karyotype (del [5q]) in patients with myelodysplastic syndrome (MDS) is the most common karyotypic abnormality in de novo MDS. An increased number of blasts and additional karyotypic abnormalities (del [al]+) are associated with a poor outcome. We analyzed the outcome of allogeneic hematopoietic cell transplants (HCT) in patients suffering from MDS with only del (5q) or del (5q)+. A total of 162 patients, of median age 54 years (range, 9 to 73), having MDS and del (5q) abnormalities received HCT from identical siblings (n = 87) or unrelated donors (n = 75). The cumulative incidence of nonrelapse mortality and relapse incidence at 4 years was 29% (95% CI, 22 to 36) and 46% (95% CI, 38 to 54), whereas the estimated 4 year survival, relapse-free and overall, was 25% (95% CI, 18 to 33) and 30% (95% CI, 23 to 38), respectively. In a multivariate analysis patients with del (5q) and a blast excess displayed poorer survival (hazard ratio, 2.38; 95% CI, 1.44 to 3.93; P <.001), whereas female recipient sex resulted in improved survival (hazard ratio, .61; 95% CI, .41 to .90; P = .01). We conclude that allogeneic HCT can cure a subset of patients with MDS and a del (5q) abnormality. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：507 / 513

页数：7

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