The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population

被引:5
|
作者
Ou, Zejin [1 ]
Wang, Guanghai [1 ]
Li, Qiang [2 ]
Ma, Zuliang [1 ]
Lin, Danmiao [1 ]
Dai, Meng [3 ]
Zou, Fei [1 ]
机构
[1] Southern Med Univ, Dept Occupat Hlth & Occupat Med, Sch Publ Hlth & Trop Med, Guangzhou 510515, Guangdong, Peoples R China
[2] Southern Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou 510515, Guangdong, Peoples R China
[3] Southern Med Univ, Nanfang Hosp, Hlth Management Ctr, Guangzhou 510515, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Association study; BMI; Obesity; Dyslipidemia; LOW-DENSITY-LIPOPROTEIN; EXTRACELLULAR-MATRIX; ADIPOSE-TISSUE; PPAR-GAMMA; FIBRONECTIN; ATHEROSCLEROSIS; CHOLESTEROL; HOMEOSTASIS; PROGRESSION; EXPRESSION;
D O I
10.1016/j.gene.2013.05.028
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Cathepsin S (CTSS) played an important role in the etiology of cardiovascular disease and metabolic syndrome. Few studies had been reported on the association between the polymorphisms of CTSS and metabolic disorders in Asian population. Therefore we explored the association between the polymorphisms of CTSS and metabolic disorders in a Chinese Han population. The subjects were a Chinese Han cohort with 1160 participants, and the genotyping was performed with PCR-RFLP. Polymorphism rs16827671 was associated with BMI and serum total cholesterol (P = 0.001; P = 0.02, respectively). Subjects with CT genotype of rs16827671 had a higher risk of hypercholesterolemia (OR = 1.64, 95% CI: 1.15-233, P = 0.006) compared with TT genotype. Subjects with AG genotype of rs11576175 had lower risks of hypertriglyceridemia and borderline hypercholesterolemia (OR = 0.52, 95% CI: 0.36-0.73, P = 0.0001; OR = 0.52, 95% CI: 035-0.77, P = 0.001, respectively) compared with GG genotype. Compared with the haplotype TG, haplotype TA had a lower risk of hypertriglyceridemia and a higher risk of borderline hypercholesterolemia (OR=0.62, 95% CI: 0.44-0.88, P = 0.002; OR = 1.59, 95% CI: 1.10-231, P = 0.008, respectively), and haplotype CA had a lower risk of hypercholesterolemia (OR = 035,95% CI: 0.18-0.68, P = 0.002). In conclusion, we found that the genetic polymorphisms of CTSS were associated with metabolic disorders in a Chinese Han population, which would enrich the knowledge on genetic mechanisms of the pathogenesis of metabolic disorders. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:385 / 389
页数:5
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