Sodium Hydroxide Catalyzed N-Alkylation of (Hetero) Aromatic Primary Amines and N1,C5-Dialkylation of 4-Phenyl-2-aminothiazoles with Benzyl Alcohols

被引：20
|
作者：
Donthiri, Ramachandra Reddy [1 ]
Pappula, Venkatanarayana [1 ]
Mohan, Darapaneni Chandra [1 ]
Gaywala, Hiren H. [1 ]
Adimurthy, Subbarayappa [1 ]
机构：
[1] CSIR Cent Salt & Marine Chem Res Inst, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 13期
关键词：
AEROBIC OXIDATION; DERIVATIVES; IMINES;
D O I：
10.1021/jo400834h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. With 1 equiv of NaOH, N-1,C-5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N-1,C-5-dialkylated products through hydride ion transformation from alcohol.
引用
收藏
页码：6775 / 6781
页数：7
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