Iron-Catalyzed [4C+1N] Cyclization of 4-Acetylenic Ketones with Primary Amines: Synthesis of 5-(Aryl)alkylidene-4,5-dihydropyrroles

被引：12

作者：

Sun, Bo ^{[1
,2
]}

Ma, Quan ^{[2
]}

Wang, Yeming ^{[3
]}

Zhao, Yuegang ^{[2
]}

Liao, Peiqiu ^{[1
]}

Bi, Xihe ^{[1
,4
]}

机构：

[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

[2] Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China

[3] Jilin Normal Univ, Dept Chem, Siping 136000, Peoples R China

[4] State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 34期

基金：

中国国家自然科学基金;

关键词：

Amines; Cyclization; Iron; Ketones; Nitrogen heterocycles; OXO KETENE DITHIOACETALS; PROPARGYLIC ALCOHOLS; 3+2 CYCLOADDITION; TERMINAL ALKYNES; ALDEHYDES; 2,3-DIHYDROPYRROLES; HYDROAMINATION; HYDROAZIDATION; HETEROCYCLES; DERIVATIVES;

D O I：

10.1002/ejoc.201403097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally friendly route to fully substituted 4,5-dihydropyrroles was developed through the iron-catalyzed [4C+1N] cyclization of 4-acetylenic ketones with primary amines in 1,5-pentanediol.

引用

页码：7552 / 7555

页数：4

共 29 条

[1] Iron-catalyzed synthesis of polysubstituted pyrroles via [4C+1N] cyclization of 4-acetylenic ketones with primary amines
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[10] Synthesis of 5-Aryl-5H-pyrido[2',1':2,3]imidazo[4,5-b]indoles by Domino Pd- and Cu-Catalyzed C-N Coupling Reactions
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