Factor VII-activating protease in patients with acute deep venous thrombosis

被引:31
|
作者
Sidelmann, Johannes J. [1 ,2 ]
Vitzthum, Frank [3 ]
Funding, Eva [2 ]
Muenster, Anna-Marie B. [2 ]
Gram, Jorgen [1 ,2 ]
Jespersen, Jorgen [1 ,2 ]
机构
[1] Univ So Denmark, Inst Publ Hlth, Unit Thrombosis Res, DK-6700 Esbjerg, Denmark
[2] Hosp SW Denmark, Dept Clin Biochem, Esbjerg, Denmark
[3] A Siemens Co, Dade Behring Marburg GmbH, Marburg, Germany
关键词
Factor VII-activating protease; Marburg I polymorphism; Deep venous thrombosis; C-reactive protein; Prothrombin fragment 1+2; Inflammation;
D O I
10.1016/j.thromres.2008.02.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Factor VII-activating protease (FSAP) is involved in haemostasis and inflammation. FSAP cleaves single chain urokinase-type plasminogen activator (scu-PA). The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene leads to the expression of a FSAP variant with reduced ability to activate scu-PA, without affecting the ability to activate coagulation Factor VII (FVII). Previous studies have investigated the association of the 1601GA genotype with incidence and progression of carotid stenosis and deep venous thrombosis (DVT). The present study is the first to evaluate the potential association between the FSAP phenotype and DVT. We studied the association between the 1601G/A polymorphism, FSAP activity, FSAP antigen, Factor Vila (FVIIa), prothrombin fragment 1+2 (F1+2), and C-reactive protein (CRP) in plasmas of 170 patients suspected for DVT FSAP genotypes were equally distributed in patients with (n=64) and without DVT (n=106), (P=0.94). The 1601GA genotype was associated with significant reduction of FSAP activity (P<0.001) and FSAP antigen levels (P=0.04). Patients with DVT showed significantly higher FSAP activity (P=0.008), FSAP antigen (P=0.003), and F1+2 levels (P<0.001) than patients without DVT. The association between the FSAP measures and DVT disappeared when adjusted for CRP levels. F1+2 correlated positively to FSAP antigen (P=0.01), while FVIIa-levets were comparable in patients with and without DVT. We conclude that even though FSAP measures are significantly increased in patients with acute DVT, alterations in the scu-PA activating properties of FSAP are presumably not markedly involved in the development of acute DVT, and that the association between FSAP and DVT disappears after adjustment for CRP. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:848 / 853
页数:6
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