Simulated unbinding and binding of fatty acid substrates in the cyclooxygenase site of prostaglandin H2 synthase-1

被引：0
|
作者：
Molnar, F
Norris, LS
Schulten, K
机构：
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[2] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
来源：
BIOPHYSICAL JOURNAL | 1999年 / 76卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
引用
收藏
页码：A401 / A401
页数：1
相关论文
共 50 条
  • [31] The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1:: Structural insights into an unusual peroxidase
    Gupta, K
    Selinsky, BS
    Kaub, CJ
    Katz, AK
    Loll, PJ
    JOURNAL OF MOLECULAR BIOLOGY, 2004, 335 (02) : 503 - 518
  • [32] Increased response to prostaglandin H2 precedes changes in PGH synthase-1 expression in the SHR aorta
    Ge, T
    Vanhoutte, PM
    Boulanger, CM
    ACTA PHARMACOLOGICA SINICA, 1999, 20 (12): : 1087 - 1092
  • [33] ENHANCED PRODUCTION OF PROSTAGLANDIN-E2 AND EXPRESSION OF PROSTAGLANDIN-G2/H2 SYNTHASE-1 AND SYNTHASE-2 BY THP-1 CELLS
    FASANO, MB
    MCCALL, CE
    CLINICAL RESEARCH, 1993, 41 (02): : A398 - A398
  • [34] Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products
    Thuresson, ED
    Lakkides, KM
    Smith, WL
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) : 8501 - 8507
  • [35] Comparison of prostaglandin H synthase-1 and-2 structural stabilities
    Xiao, GS
    Chen, W
    Kulmacz, RJ
    EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, IMFLAMMATION AND RADIATION INJURY, 4, 1999, 469 : 115 - 118
  • [36] Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity
    Ikeda-Matsuo, Y.
    Hirayama, Y.
    Ota, A.
    Uematsu, S.
    Akira, S.
    Sasaki, Y.
    BRITISH JOURNAL OF PHARMACOLOGY, 2010, 159 (05) : 1174 - 1186
  • [37] Prostaglandin H2 synthase-1 and -2 expression in guinea pig gestational tissues during late pregnancy and parturition
    Welsh, T
    Mitchell, CM
    Walters, WA
    Mesiano, S
    Zakar, T
    JOURNAL OF PHYSIOLOGY-LONDON, 2005, 569 (03): : 903 - 912
  • [38] Peroxidase site of prostaglandin endoperoxide H synthase-1: Docking and molecular dynamics studies with a prostaglandin endoperoxide analog
    Seibold, SA
    Smith, WL
    Cukier, RI
    JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (26): : 9297 - 9305
  • [39] Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2
    Tsai, Ah-lim
    Wu, Gang
    Rogge, Corina E.
    Lue, Jian-Ming
    Peng, Sheng
    van der Donk, Wilfred A.
    Palmer, Graham
    Gerfen, Gary J.
    Kulmacz, Richard J.
    JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (03) : 366 - 374
  • [40] ENDOTOXIN TOLERANCE IS ASSOCIATED WITH DECREASED PROSTAGLANDIN-H SYNTHASE-1 AND SYNTHASE-2
    GEISEL, J
    COOK, JA
    ASHTON, SH
    WISE, WC
    HALUSHKA, PV
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1994, 267 (04): : C1067 - C1072
12345