Epidemiological evidence against a role for C-reactive protein causing leptin resistance

被引：5

作者：

Rutter, M. K. ^{[1
,2
]}

Sattar, N. ^{[3
]}

Tajar, A. ^{[4
,5
]}

O'Neill, T. W. ^{[6
]}

Lee, D. M. ^{[6
]}

Bartfai, G. ^{[7
]}

Boonen, S. ^{[8
,9
]}

Casanueva, F. F. ^{[10
,11
]}

Finn, J. D. ^{[6
]}

Forti, G. ^{[12
]}

Giwercman, A. ^{[13
]}

Han, T. S. ^{[14
]}

Huhtaniemi, I. T. ^{[15
]}

Kula, K. ^{[16
]}

Lean, M. E. J. ^{[17
]}

Pendleton, N. ^{[18
]}

Punab, M. ^{[19
]}

Silman, A. J. ^{[6
]}

Vanderschueren, D. ^{[20
]}

Lowe, G. ^{[21
]}

O'Rahilly, S. ^{[22
]}

Morris, R. W. ^{[23
]}

Wu, F. C. ^{[1
,24
]}

Wannamethee, S. G. ^{[23
]}

机构：

[1] Univ Manchester, Endocrinol & Diabet Grp, Dev Biomed Res Grp, Manchester M13 9PT, Lancs, England

[2] Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Diabet Ctr, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[3] Univ Glasgow, British Heart Fdn, Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland

[4] Univ Oxford, Ctr Stat Med, Oxford, England

[5] Oxford Biomed Res Ctr, Oxford, England

[6] Univ Manchester, Arthrit Res UK Epidemiol Unit, Manchester M13 9PT, Lancs, England

[7] Albert Szent Gyorgy Med Univ, Dept Obstet Gynaecol & Androl, Szeged, Hungary

[8] Katholieke Univ Leuven, Div Gerontol & Geriatr, Dept Expt Med, Louvain, Belgium

[9] Katholieke Univ Leuven, Ctr Musculoskeletal Res, Dept Expt Med, Louvain, Belgium

[10] Univ Santiago de Compostela, CHUS, Dept Med, Santiago De Compostela, Spain

[11] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Madrid, Spain

[12] Univ Florence, Dept Clin Physiopathol, Androl Unit, Florence, Italy

[13] Lund Univ, Reprod Med Ctr, Malmo Univ Hosp, Malmo, Sweden

[14] Royal Free Hosp, Dept Endocrinol, Royal Free & Univ Coll Hosp Med Sch, London NW3 2QG, England

[15] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London, England

[16] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Lodz, Poland

[17] Univ Glasgow, Dept Human Nutr, Glasgow, Lanark, Scotland

[18] Univ Manchester, Hope Hosp, Salford M6 8HD, Lancs, England

[19] Tartu Univ Clin, Androl Unit, United Labs, Tartu, Estonia

[20] Katholieke Univ Leuven, Dept Androl & Endocrinol, Louvain, Belgium

[21] Univ Glasgow, Royal Infirm, Div Cardiovasc & Med Sci, Glasgow, Lanark, Scotland

[22] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QQ, England

[23] UCL, Sch Med, Dept Primary Care & Populat Hlth, London W1N 8AA, England

[24] Cent Manchester Univ Hosp NHS Fdn Trust, Dept Endocrinol, Manchester, Lancs, England

来源：

EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2013年 / 168卷 / 01期

关键词：

RISK; ADIPOSITY; MEN;

D O I：

10.1530/EJE-12-0348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans, and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity. Design and methods: We assessed four measures of adiposity: BMI, waist circumference, fat mass and body fat (%) in 2113 British Regional Heart Study (BRHS) men (mean (S.D.) age 69 (5) years), with replication in 760 (age 69 (6) years) European Male Ageing Study (EMAS) subjects. Results: In BRHS subjects, leptin correlated with CRP (Spearman's r=0.22, P<0.0001). Leptin and CRP correlated with all four measures of adiposity (r value range: 0.22-0.57, all P<0.0001). Age-adjusted mean levels for adiposity measures increased in relation to leptin levels, but CRP level did not consistently influence the beta-coefficients of the regression lines in a CRP-stratified analysis. In BRHS subjects, the BMI vs leptin relationship demonstrated a weak statistical interaction with CRP (P=0.04). We observed no similar interaction in EMAS subjects and no significant interactions with other measures of adiposity in BRHS or EMAS cohorts. Conclusion: We have shown that plasma CRP has little influence on the relationship between measures of adiposity and serum leptin levels in these middle-aged and elderly male European cohorts. This study provides epidemiological evidence against CRP having a significant role in causing leptin resistance. European Journal of Endocrinology 168 101-106

引用

页码：101 / 106

页数：6

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