The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A

被引：66

作者：

Weisser, Melanie ^{[1
]}

Voigts-Hoffmann, Felix ^{[1
]}

Rabl, Julius ^{[1
]}

Leibundgut, Marc ^{[1
]}

Ban, Nenad ^{[1
]}

机构：

[1] ETH, Inst Mol Biol & Biophys, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

SEQUENCE ALIGNMENT EDITOR; START CODON SELECTION; INITIATION-FACTORS; 1A; TRANSLATION INITIATION; IN-VIVO; BINDING; QUALITY; RNA; RECOGNITION; SOFTWARE;

D O I：

10.1038/nsmb.2622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 angstrom. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.

引用

页码：1015 / +

页数：4

共 50 条

[31] A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon
Maag, D
Fekete, CA
Gryczynski, Z
Lorsch, JR
MOLECULAR CELL, 2005, 17 (02) : 265 - 275
[32] Mapping of the eukaryotic initiation factor eIF-1A gene, Eif1a, to mouse Chromosome 12D-E by FISH
Kikyo, N
Tada, M
Tada, T
Surani, MA
MAMMALIAN GENOME, 1997, 8 (05) : 376 - 376
[33] The Interaction between Eukaryotic Initiation Factor 1A and eIF5 Retains eIF1 within Scanning Preinitiation Complexes
Luna, Rafael E.
Arthanari, Haribabu
Hiraishi, Hiroyuki
Akabayov, Barak
Tang, Leiming
Cox, Christian
Markus, Michelle A.
Luna, Lunet E.
Ikeda, Yuka
Watanabe, Ryosuke
Bedoya, Edward
Yu, Cathy
Alikhan, Shums
Wagner, Gerhard
Asano, Katsura
BIOCHEMISTRY, 2013, 52 (52) : 9510 - 9518
[34] The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G
Yamamoto, Y
Singh, CR
Marintchev, A
Hall, NS
Hannig, EM
Wagner, G
Asano, K
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (45) : 16164 - 16169
[35] Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo
Olsen, DS
Savner, EM
Mathew, A
Zhang, F
Krishnamoorthy, T
Phan, L
Hinnebusch, AG
EMBO JOURNAL, 2003, 22 (02): : 193 - 204
[36] EUKARYOTIC TRANSLATION INITIATION-FACTOR EIF1A FROM SACCHAROMYCES-CEREVISIAE
KAINUMA, M
WEI, CL
HERSHEY, JWB
FASEB JOURNAL, 1995, 9 (06): : A1427 - A1427
[37] X-ray structures of eIF5B and the eIF5B-eIF1A complex: the conformational flexibility of eIF5B is restricted on the ribosome by interaction with eIF1A
Zheng, Aiping
Yu, Jian
Yamamoto, Reo
Ose, Toyoyuki
Tanaka, Isao
Yao, Min
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 2014, 70 : 3090 - 3098
[38] Function of eukaryotic translation initiation factor 1A (eIF1A) (formerly called eIF-4C) in initiation of protein synthesis
Chaudhuri, J
Si, K
Maitra, U
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 7883 - 7891
[39] Mapping of the eukaryotic initiation factor eIF-lA gene, Eif1a, to mouse chromosome 12D-E by FISH
N. Kikyo
M. Tada
T. Tada
M. A. Surani
Mammalian Genome, 1997, 8 : 376 - 376
[40] Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits
Grove, Daisy J.
Levine, Daniel J.
Kearse, Michael G.
NUCLEIC ACIDS RESEARCH, 2023, 51 (18) : 9983 - 10000

← 1 2 3 4 5 →