The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A

被引：66

作者：

Weisser, Melanie ^{[1
]}

Voigts-Hoffmann, Felix ^{[1
]}

Rabl, Julius ^{[1
]}

Leibundgut, Marc ^{[1
]}

Ban, Nenad ^{[1
]}

机构：

[1] ETH, Inst Mol Biol & Biophys, Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 08期

基金：

瑞士国家科学基金会;

关键词：

SEQUENCE ALIGNMENT EDITOR; START CODON SELECTION; INITIATION-FACTORS; 1A; TRANSLATION INITIATION; IN-VIVO; BINDING; QUALITY; RNA; RECOGNITION; SOFTWARE;

D O I：

10.1038/nsmb.2622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 angstrom. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.

引用

页码：1015 / +

页数：4

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