The molecular regulation of Th1 development mediated by IL-12 signaling and Stat4 activation

被引：0
|
作者：
Ouyang, W [1 ]
Jacobsen, N [1 ]
Gorham, JG [1 ]
Ranganath, SH [1 ]
Weindel, K [1 ]
Murphy, TL [1 ]
Murphy, KM [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol, HHMI, St Louis, MO 63110 USA
来源：
FASEB JOURNAL | 1999年 / 13卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：A651 / A651
页数：1
相关论文
共 50 条
  • [21] IL-23R-activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity
    Lee, Priscilla W.
    Smith, Alan J.
    Yang, Yuhong
    Selhorst, Amanda J.
    Liu, Yue
    Racke, Michael K.
    Lovett-Racke, Amy E.
    JCI INSIGHT, 2017, 2 (17):
  • [22] IL-12 induced STAT4 activation plays a role in pro-inflammatory neutrophil functions
    Keeter, William Coles
    Moriarty, Alina
    Butcher, Matthew J.
    Ma, Kaiwen W.
    Nadler, Jerry L.
    Galkina, Elena
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [23] Reciprocal effects of IFN-β and IL-12 on STAT4 activation and cytokine induction in T cells
    Fahey, Angela J.
    Robins, R. Adrian
    Constantinescu, Cris S.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (06) : 1562 - 1567
  • [24] IFN-gamma and IL-4 promote TH1 and TH2 development by differentially modulating high affinity IL-12 receptor expression and IL-12-induced activation of Stat1 and Stat5.
    Gollob, JA
    Mahajan, S
    Rudders, SA
    Ritz, J
    Frank, DA
    BLOOD, 1996, 88 (10) : 1100 - 1100
  • [25] Comparison of desiccating stress without or with inhibition of tear secretion on activation of the IL-12/STAT4 pathway
    Yu, Zhiyuan
    Alam, Jahan
    De Paiva, Cintia
    Pflugfelder, Stephen
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2020, 61 (07)
  • [26] Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation
    Duy Pham
    Yu, Qing
    Walline, Crystal C.
    Muthukrishnan, Rajarajeswari
    Blum, Janice S.
    Kaplan, Mark H.
    JOURNAL OF IMMUNOLOGY, 2013, 191 (02): : 902 - 911
  • [27] The production of IFN-γ by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4
    Schindler, H
    Lutz, MB
    Röllinghoff, M
    Bogdan, C
    JOURNAL OF IMMUNOLOGY, 2001, 166 (05): : 3075 - 3082
  • [28] Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4
    Kato, A
    Graul-Layman, A
    Edwards, MJ
    Lentsch, AB
    TRANSPLANTATION, 2002, 73 (07) : 1142 - 1145
  • [29] STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
    Stamm, LM
    Satoskar, AA
    Ghosh, SK
    David, JR
    Satoskar, AR
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1999, 29 (08) : 2524 - 2529
  • [30] Stat-4 mediated IL-12 signaling pathway is critical for development of protective immunity in experimental cysticercosis
    Terrazas, LI
    Satoskar, AR
    Tena, CA
    Graullera, V
    Rodriguez-Sosa, M
    FASEB JOURNAL, 2003, 17 (07): : C197 - C197
12345