Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

被引：39
|
作者：
Wu, Jianjun [1 ]
Yang, Ti [1 ]
Li, Xun [1 ]
Yang, Qiaoyuan [1 ]
Liu, Rong [1 ,2 ]
Huang, Jinkun [1 ,2 ]
Li, Yuanqi [1 ]
Yang, Chengfeng [3 ,4 ]
Jiang, Yiguo [1 ]
机构：
[1] Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China
[3] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA
[4] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA
来源：
TOXICOLOGY AND APPLIED PHARMACOLOGY | 2013年 / 267卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Serum; miR-206; miR-133b; Lung carcinogenesis; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; MICRORNA EXPRESSION; MALIGNANT-TRANSFORMATION; CIRCULATING MICRORNAS; F344; RATS; BIOMARKERS; TUMORIGENESIS; BIOCHEMISTRY; SIGNATURES; CIGARETTE; INVASION;
D O I：
10.1016/j.taap.2013.01.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The alteration of microRNA (miRNA) expression plays an important role in chemical carcinogenesis. Presently, few reports have been published that concern the significance of circulating miRNAs in lung carcinogenesis induced by environmental carcinogens. The purpose of this study was to identify serum miRNAs that could be associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Male F344 rats were systemically administered with NNK. The rat serum differential expression profiles of miRNAs were analyzed by small RNA solexa sequencing. Using quantitative real-time PCR, the differentially expressed serum miRNAs were identified in each individual rat. Serum miR-206 and miR-133b were selected for further identification in rat serum at different stages of lung carcinogenesis; we detected the levels of serum miR-206 and miR-133b in lung cancer tissues induced by NNK. NNK causes significant alteration of serum miRNA expression. Compared to the control group, serum miR-206 and miR-133b were significantly up-regulated in the early stage of NNK-induced lung carcinogenesis. miR-206 and miR-133b exhibited low-expression in lung cancer tissues. Our results demonstrate that lung carcinogen NNK exposure changes the expression of serum miRNAs. Serum miR-206 and miR-133b could be associated with lung carcinogenesis induced by NNK. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：238 / 246
页数：9
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