Cytomorphometric changes in hippocampal CA1 neurons exposed to simulated microgravity using rats as model

被引:32
|
作者
Ranjan, Amit [1 ,2 ]
Behari, Jitendra [2 ]
Mallick, Birendra N. [1 ]
机构
[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India
[2] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India
来源
FRONTIERS IN NEUROLOGY | 2014年 / 5卷
关键词
dendritic arborization; Golgi-Cox; learning and memory; length of active zone; neuronal plasticity; spine density; DENDRITIC SPINE DENSITY; HEAD-DOWN TILT; PYRAMIDAL NEURONS; SYNAPTIC PLASTICITY; MENTAL PERFORMANCE; PROTEOMIC ANALYSIS; SHORT-TERM; IN-VIVO; SPACE; MEMORY;
D O I
10.3389/fneur.2014.00077
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Microgravity and sleep loss lead to cognitive and learning deficits. These behavioral alterations are likely to be associated with cytomorphological changes and loss of neurons. To understand the phenomenon, we exposed rats (225-275 g) to 14 days simulated micro gravity (SMg) and compared its effects on CA1 hippocampal neuronal plasticity, with that of normal cage control rats. We observed that the mean area, perimeter, synaptic cleft, and length of active zone of CA1 hippocampal neurons significantly decreased while dendritic arborization and number of spines significantly increased in SMg group as compared with controls. The mean thickness of the postsynaptic density and total dendritic length remained unaltered. The changes may be a compensatory effect induced by exposure to microgravity; however, the effects may be transient or permanent, which need further study. These findings may be useful for designing effective prevention for those, including the astronauts, exposed to microgravity. Further, subject to confirmation, we propose that SMg exposure might be useful for recovery of stroke patients.
引用
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页数:10
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